DESI_JEDI-IMAGING

Development of mass spectrometric techniques for 3D imaging and in-vivo analysis of biological tissues

Coordinatore	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	1˙750˙000 €
EC contributo	1˙750˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2007-StG
Funding Scheme	ERC-SG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-09-01   -   2013-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	JUSTUS-LIEBIG-UNIVERSITAET GIESSEN  Organization address address: Ludwigstrasse 23 city: GIESSEN postcode: 35390 contact info Titolo: Dr. Nome: Jamilah Cognome: Michel Email: send email Telefono: -12814 Fax: -12800	DE (GIESSEN)	beneficiary	0.00
2	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Dr. Nome: Zoltan Cognome: Takats Email: send email Telefono: +44 207 594 1419	UK (LONDON)	hostInstitution	0.00
3	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Tatjana Cognome: Palalic Email: send email Telefono: +44 20 7594 6265	UK (LONDON)	hostInstitution	0.00

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 Obiettivo del progetto (Objective)

'Recent development of atmospheric pressure desorption ionization methods has opened a unique area of application for analytical mass spectrometry. Most of these methods do not require any modification of samples, and this feature, together with the minimal invasiveness of these methods allows direct analytical interrogation of biological tissues, even the real-time, in-vivo observation of biochemical processes. The proposed research focuses on the development of atmospheric pressure desorption ionization mass spectrometric methods for the characterization of biological tissues. The first question to answer is aimed at the nature of information which can be obtained, using a variety of desorption ionization methods including desorption electrospray ionization and jet desorption ionization methods. Preliminary results show, that APDI-MS methods provide information on lipids, metabolic compounds, drugs and certain proteins. First task of the proposed research is to implement a chemical imaging system, which is capable of producing 3D concentration distribution functions for various constituents of tissue samples. The developed methodology will be used to tackle fundamental pathophysiological problems including development of various malignant tumors. A database will be created for the unequivocal identification of various tissues including healthy and malignant tissue samples. In-vivo applications of MS will also be developed. JeDI-MS,similarly to water jet surgery, also utilizes high velocity water jet can directly be used as an intelligent scalpel. Real-time in-situ tissue identification has the potential of revolutionizing cancer surgery, since this way the amount of removed tissue can be minimized, while the tumor removal efficiency is maximized. The identical experimental platform can also be used to gather real-time in-situ metabolic information, which can help to understand pathophysiological changes.'