NBO

Novel Biomimetic Organocatalysts

Coordinatore	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Ireland [IE]
Totale costo	1˙249˙772 €
EC contributo	1˙249˙772 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2007-StG
Funding Scheme	ERC-SG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-10-01   -   2014-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN  Organization address address: College Green - city: DUBLIN postcode: 2 contact info Titolo: Ms. Nome: Deirdre Cognome: Savage Email: send email Telefono: +353 1 8961942 Fax: +353 1 7071633	IE (DUBLIN)	hostInstitution	0.00
2	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN  Organization address address: College Green - city: DUBLIN postcode: 2 contact info Titolo: Prof. Nome: Stephen Cognome: Connon Email: send email Telefono: 35318961306 Fax: 35316712826	IE (DUBLIN)	hostInstitution	0.00

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 Obiettivo del progetto (Objective)

'The primary aim of this project is to substantially expand the frontiers of current benchmark organocatalytic technology by the design, preparation and evaluation of the first class of thiol-based nucleophilic catalyst capable of emulating the action of NAD-dependant enzymes such as aldehyde dehydrogenases, which promote the chemoselective oxidation/reduction of aldehyde substrates under mild conditions in aqueous media. The proposed artificial enzymes are designed biomimetically (in the true sense of the word) – only careful examination of the core enzyme competencies, modes-of-action and active sites has guided the design process. One of the key issues which this proposal addresses is the inherent difficulty associated with the design of artificial cofactor-dependent enzymes due to the requirement for a) efficient recognition by the catalyst of both the substrate and the cofactor, and b) the exertion of control over their encounter in the active site. We intend to tackle this challenge by covalently attaching groups functionally equivalent to the catalytically active residues of aldehyde dehydrogenases to a rigid NAD analogue in a manner which allows for their synergistic and biomimetic cooperation. Structure determination/mechanistic studies and the application of these new catalysts in a range of oxidations/reductions (we envisage that this project will result in the first organocatalyst able to demonstrably promote either - depending on the reaction conditions), (dynamic) kinetic resolutions, desymmetrisations, and ligations) will be undertaken and the development of catalytic processes for reactions currently outside the scope of any catalytic methodology is a clear long-term goal. We also wish to pursue the application of this potentially groundbreaking nucleophilic catalytic technology (for which no efficient organocatalysts have been thus far reported) toward the selective synthesis of enantiopure building blocks and pharmaceutically relevant molecules.'