OPENTOX

OpenTox - An Open Source Predictive Toxicology Framework

Coordinatore	DOUGLAS CONNECT    more  Organization address address: Baermeggenweg 14 city: ZEININGEN postcode: 4314 contact info Titolo: Ms. Nome: Nicki Cognome: Douglas Email: send email Telefono: -1332 Fax: -4782
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	3˙775˙680 €
EC contributo	2˙975˙360 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-09-01   -   2011-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	DOUGLAS CONNECT  Organization address address: Baermeggenweg 14 city: ZEININGEN postcode: 4314 contact info Titolo: Ms. Nome: Nicki Cognome: Douglas Email: send email Telefono: -1332 Fax: -4782	CH (ZEININGEN)	coordinator	0.00
2	ALBERT-LUDWIGS-UNIVERSITAET FREIBURG  Organization address address: FAHNENBERGPLATZ city: FREIBURG postcode: 79085 contact info Titolo: Dr. Nome: Andreas Cognome: Karwath Email: send email Telefono: -8944 Fax: -8922	DE (FREIBURG)	participant	0.00
3	DAVID ANTHONY GALLAGHER  Organization address address: "Park Mews, Park Road 3" city: CONGRESBURY postcode: BS49 5HR contact info Titolo: Dr. Nome: David Cognome: Gallagher Email: send email Telefono: -446117 Fax: -	UK (CONGRESBURY)	participant	0.00
4	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V  Organization address address: Hansastrasse 27C city: MUENCHEN postcode: 80686 contact info Titolo: Ms. Nome: Andrea Cognome: Zeumann Email: send email Telefono: -3968 Fax: -8779	DE (MUENCHEN)	participant	0.00
5	HELMA CHRISTOPH  Organization address address: TALSTRASSE 20 city: FREIBURG postcode: 79102 contact info Titolo: Dr. Nome: Christoph Cognome: Helma Email: send email Telefono: -7592050 Fax: -	DE (FREIBURG)	participant	0.00
6	IDEACONSULT LIMITED LIABILITY COMPANY  Organization address address: ANGEL KANCHEV 4 city: SOFIA postcode: 1000 contact info Titolo: Mr. Nome: Vedrin Cognome: Jeliazkov Email: send email Telefono: +359 887818654 Fax: +359 2 9526265	BG (SOFIA)	participant	0.00
7	INSTITUTE OF BIOMEDICAL CHEMISTRY - RUSSIAN ACADEMY OF SCIENCES  Organization address address: POGODINSKAYA STREET 10 city: MOSKVA postcode: 119121 contact info Titolo: Prof. Nome: Poroikov Cognome: Vladimir Email: send email Telefono: +007 495 245-27-53 Fax: +007 495 245-08-57	RU (MOSKVA)	participant	0.00
8	ISTITUTO SUPERIORE DI SANITA  Organization address address: Viale Regina Elena 299 city: ROMA postcode: 161 contact info Titolo: Ms. Nome: Rosa Maria Cognome: Martoccia Email: send email Telefono: -49902655 Fax: -3473	IT (ROMA)	participant	0.00
9	NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA  Organization address address: HEROON POLYTECHNIOU 9 ZOGRAPHOU CAMPUS city: ATHINA postcode: 15780 contact info Titolo: Prof. Nome: Yannis Cognome: Polyzos Email: send email Telefono: -7722230 Fax: -7722140	EL (ATHINA)	participant	0.00
10	SEASCAPE LEARNING CO PRIVATE LTD  Organization address address: "DOUBLE STOREY, NEW RAJINDER NGR 271" city: NEW DELHI postcode: 110060 contact info Titolo: Mr. Nome: Sunil Cognome: Chawla Email: send email Telefono: 91-9810305923 Fax: 91 20 2569 0087	IN (NEW DELHI)	participant	0.00
11	TECHNISCHE UNIVERSITAET MUENCHEN  Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 contact info Titolo: Ms. Nome: Ulrike Cognome: Ronchetti Email: send email Telefono: +49 89 289 22 616 Fax: +49 89 289 22 620	DE (MUENCHEN)	participant	0.00

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 Obiettivo del progetto (Objective)

'The goal of the OpenTox project is to develop a predictive toxicology framework with a unified access to toxicological data, (Q)SAR models and supporting information. It will provide tools for the integration of data from various sources (public and confidential), for the generation and validation of (Q)SAR models, libraries for the development and integration of new (Q)SAR algorithms, and validation routines. OpenTox will attract toxicological experts without (Q)SAR expertise as well as model and algorithm developers. It will move beyond existing attempts to solve individual research issues, by providing a flexible and user friendly framework that integrates existing solutions and new developments. OpenTox will be relevant for REACH as it gives risk assessors simple access to experimental data, (Q)SAR models and toxicological information that adheres to European and international regulatory requirements. OpenTox will be published as an open source project to allow a critical evaluation of its algorithms, to promote dissemination, and to attract external developers. Facilities for the inclusion of confidential in-house data and for accessing commercial prediction systems will be included. OpenTox will contain high-quality data and (Q)SAR models for chronic, genotoxic and carcinogenic effects. These are the endpoints with the greatest potential to reduce animal testing. The impact of OpenTox will however go beyond REACH and long-term effects, because it will be straightforward to create models for other endpoints (e.g,. sensitisation, liver-toxicity, cardio-toxicity, ecotoxicity). The proposed framework will support the development of new (Q)SAR models and algorithms by automating routine tasks, providing a testing and validation environment and allowing the easy addition of new data. For this reason we expect, that OpenTox will lead to (Q)SAR models for further toxic endpoints and generally improve the acceptance and reliability of (Q)SAR models.'