REEF

Reproductive effects of environmental chemicals in females

Coordinatore	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN    more  Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX contact info Titolo: Mr. Nome: Frederick Cognome: Stevenson-Robb Email: send email Telefono: +44 1224 272121 Fax: +44 1224 272319
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	3˙871˙325 €
EC contributo	2˙923˙363 €
Programma	FP7-ENVIRONMENT Specific Programme "Cooperation": Environment (including Climate Change)
Code Call	FP7-ENV-2007-1
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-05-01   -   2011-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN  Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX contact info Titolo: Mr. Nome: Frederick Cognome: Stevenson-Robb Email: send email Telefono: +44 1224 272121 Fax: +44 1224 272319	UK (ABERDEEN)	coordinator	0.00
2	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE  Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Mr. Nome: Angelo Cognome: Trussardi Email: send email Telefono: +33 1 34 65 20 40 Fax: +33 1 34 65 21 46	FR (PARIS CEDEX 07)	participant	0.00
3	MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG  Organization address address: UNIVERSITAETSPLATZ 10 city: HALLE (Saale) postcode: 6099 contact info Titolo: Dr. Nome: Manfred Cognome: Jank Email: send email Telefono: +49 345 5521303 Fax: +49 345 5527396	DE (HALLE (Saale))	participant	0.00
4	THE MACAULAY LAND USE RESEARCH INSTITUTE  Organization address address: Craigiebuckler city: ABERDEEN postcode: AB15 8QH contact info Titolo: Ms. Nome: Carold Cognome: Bisset Email: send email Telefono: +44 1224 498 200 Fax: +44 1224 311 556	UK (ABERDEEN)	participant	0.00
5	THE UNIVERSITY OF NOTTINGHAM  Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD contact info Titolo: Mr. Nome: Paul Cognome: Cartledge Email: send email Telefono: +44 115 951 5679 Fax: +44 115 951 3633	UK (NOTTINGHAM)	participant	0.00
6	UNIVERSITA DEGLI STUDI DI MILANO  Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 contact info Titolo: Dr. Nome: Donatella Cognome: Sacchelli Email: send email Telefono: +39 02 50318078 Fax: +39 02 50318079	IT (MILANO)	participant	0.00

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 Obiettivo del progetto (Objective)

'It is increasingly evident that in-utero exposure to environmental chemicals (ECs), including endocrine disrupting compounds (EDCs) and heavy metals, disturbs reproductive development in wildlife, domestic species and humans. Current thinking is that exposure to ECs is part of the mechanism driving increasing incidences of reproductive dysfunction in males and females, the latter characterised by statistics such as the 2% annual increase in EU breast cancer rates. Studies on a wide range of ECs, including phthalates, PCBs and dioxins, suggest the whole female reproductive tract is sensitive to chemical perturbation. However, many studies have focused on single or small numbers of ECs on short-lived rodent species at high doses. These exposure modalities have no relationship with normal human exposure. We will use a long-lived species, mono-ovulating, the sheep, with a pattern of gestational development similar to humans, exposed long-term to a broad range of ECs at low/environmental concentrations. This will provide a real-life model for human exposure. We will investigate follicle formation, oocyte maturation, ovaries, uteri and mammary glands in fetal sheep exposed in-utero and in adult offspring. Selected ECs preferentially concentrated in fetal tissues will be investigated using sheep and mouse models, the latter primarily for mechanistic studies. Our scale of investigation will encompass epigenetic right up to transgenerational effects of exposure and will utilise cutting-edge methodologies including proteomics, transcriptomics and organotypic cultures. To ensure we understand the link with human reproductive development, we will investigate EC-sensitive genes and proteins identified in the animal models in normal second trimester human fetuses and culture of fetal human ovaries with ECs identified as potential key chemicals in the animal models. This study will establish the potential risks of environmental chemicals on human female reproductive development.'