SPACEBRAIN
Space coding in hippocampo-entorhinal neuronal assemblies
| Coordinatore |
Organization address
address: HOGSKOLERINGEN 1 contact info |
| Nazionalità Coordinatore | Non specificata |
| Sito del progetto | http://www.ntnu.no/cbm/spacebrain |
| Totale costo | 7˙996˙767 € |
| EC contributo | 3˙000˙000 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH- |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-02-01 - 2011-07-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
NORGES TEKNISK-NATURVITENSKAPELIGEUNIVERSITET NTNU
Organization address
address: HOGSKOLERINGEN 1 contact info |
NO (TRONDHEIM) | coordinator | 0.00 |
| 2 |
AXONA LIMITED
Organization address
address: Green Lane 148 contact info |
UK (ST. ALBANS) | participant | 0.00 |
| 3 |
SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI
Organization address
address: VIA BONOMEA 265 contact info |
IT (TRIESTE) | participant | 0.00 |
| 4 |
UNIVERSITAET ZUERICH
Organization address
address: Raemistrasse 71 contact info |
CH (ZURICH) | participant | 0.00 |
| 5 |
UNIVERSITAETSKLINIKUM HEIDELBERG
Organization address
address: IM NEUENHEIMER FELD 672 contact info |
DE (HEIDELBERG) | participant | 0.00 |
| 6 |
UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
UK (LONDON) | participant | 0.00 |
| 7 |
WEIZMANN INSTITUTE OF SCIENCE
Organization address
address: HERZL STREET 234 contact info |
IL (REHOVOT) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Despite impressive advances in almost every field of neuroscience, our insights into brain function remain largely confined to its building blocks at the microscopic level, and to phenomenological descriptions at the macroscopic level. Understanding how complex mental functions originate from electrical and chemical processes in brain cells requires a comprehensive and integrated multi-level analysis focused on neuronal assemblies and microcircuits, where myriads of intricately connected neurons with different properties act together. We shall use the coordinator’s recent discovery of entorhinal grid cells – a key cell type in the network for spatial representation and navigation – as a model for neuronal computation in non-sensory cortical microcircuits. The crystal-like structure of the firing fields of grid cells provides an entirely new route to access the neuronal interactions responsible for pattern formation in the brain. Using a forceful combination of computational modelling and novel electrophysiological, optical and molecular research tools never applied for circuit analyses in the brain before, we shall establish the mechanisms by which microcircuits in the hippocampus and entorhinal cortex encode, maintain and update representations of location as animals move from one place to another. Insights into the underlying computations have considerable translation potential. Understanding the algorithms for spatial navigation may change the way we manage a number of diseases, including Alzheimer’s disease, which commonly begins in the entorhinal cortex and has topographical disorientation as one of its most reliable symptoms, and it may provide European industry with radically innovative concepts for the design of artificial navigating agents.'