SPACEBRAIN

Space coding in hippocampo-entorhinal neuronal assemblies

Coordinatore	more  Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 contact info Titolo: Prof. Nome: Edvard Cognome: Moser Email: send email Telefono: +47 73598278 Fax: +47 73598294
Nazionalità Coordinatore	Non specificata
Sito del progetto	http://www.ntnu.no/cbm/spacebrain
Totale costo	7˙996˙767 €
EC contributo	3˙000˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-02-01   -   2011-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	NORGES TEKNISK-NATURVITENSKAPELIGEUNIVERSITET NTNU  Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 contact info Titolo: Prof. Nome: Edvard Cognome: Moser Email: send email Telefono: +47 73598278 Fax: +47 73598294	NO (TRONDHEIM)	coordinator	0.00
2	AXONA LIMITED  Organization address address: Green Lane 148 city: ST. ALBANS postcode: AL36EU contact info Titolo: Mr. Nome: James Cognome: Donnett Email: send email Telefono: 442072000000 Fax: 442077000000	UK (ST. ALBANS)	participant	0.00
3	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI  Organization address address: VIA BONOMEA 265 city: TRIESTE postcode: 34136 contact info Titolo: Prof. Nome: Alessandro Cognome: Treves Email: send email Telefono: 390404000000 Fax: 390404000000	IT (TRIESTE)	participant	0.00
4	UNIVERSITAET ZUERICH  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Prof. Nome: Fritjof Cognome: Helmchen Email: send email Telefono: +41 446353340 Fax: +41 446353303	CH (ZURICH)	participant	0.00
5	UNIVERSITAETSKLINIKUM HEIDELBERG  Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 contact info Titolo: Mr. Nome: Thorsten Cognome: Brietz Email: send email Telefono: 496222000000 Fax: +49 6221565460	DE (HEIDELBERG)	participant	0.00
6	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Mr. Nome: Kent Cognome: Lee Email: send email Telefono: 442077000000 Fax: 442077000000	UK (LONDON)	participant	0.00
7	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Tzahor Cognome: Talia Email: send email Telefono: 97289344026 Fax: 97289344165	IL (REHOVOT)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'Despite impressive advances in almost every field of neuroscience, our insights into brain function remain largely confined to its building blocks at the microscopic level, and to phenomenological descriptions at the macroscopic level. Understanding how complex mental functions originate from electrical and chemical processes in brain cells requires a comprehensive and integrated multi-level analysis focused on neuronal assemblies and microcircuits, where myriads of intricately connected neurons with different properties act together. We shall use the coordinator’s recent discovery of entorhinal grid cells – a key cell type in the network for spatial representation and navigation – as a model for neuronal computation in non-sensory cortical microcircuits. The crystal-like structure of the firing fields of grid cells provides an entirely new route to access the neuronal interactions responsible for pattern formation in the brain. Using a forceful combination of computational modelling and novel electrophysiological, optical and molecular research tools never applied for circuit analyses in the brain before, we shall establish the mechanisms by which microcircuits in the hippocampus and entorhinal cortex encode, maintain and update representations of location as animals move from one place to another. Insights into the underlying computations have considerable translation potential. Understanding the algorithms for spatial navigation may change the way we manage a number of diseases, including Alzheimer’s disease, which commonly begins in the entorhinal cortex and has topographical disorientation as one of its most reliable symptoms, and it may provide European industry with radically innovative concepts for the design of artificial navigating agents.'