IMECS

Identification of Mechanisms Correlating with Susceptibility for Avian Influenza

Coordinatore	RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN    more  Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA contact info Titolo: Ms. Nome: Marjon Cognome: Hartwigsen Email: send email Telefono: 31302742038 Fax: 31302744486
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	3˙668˙819 €
EC contributo	2˙797˙287 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-04-01   -   2012-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN  Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA contact info Titolo: Ms. Nome: Marjon Cognome: Hartwigsen Email: send email Telefono: 31302742038 Fax: 31302744486	NL (BILTHOVEN)	coordinator	0.00
2	"MINISTERIE VAN VOLKSGEZONDHEID, WELZIJN EN SPORT"  Organization address address: PARNASSUSPLEIN 5 city: DEN HAAG postcode: 2500 EJ contact info Titolo: Mr. Nome: Ernst Cognome: Soethout Email: send email Telefono: +3130 2743200 Fax: +31 302744439	NL (DEN HAAG)	participant	0.00
3	ACADEMISCH ZIEKENHUIS LEIDEN  Organization address address: Albinusdreef 2 city: LEIDEN postcode: 2333 ZA contact info Titolo: Ms. Nome: Sonja Cognome: Croes Email: send email Telefono: +31 715264765 Fax: +31 715266831	NL (LEIDEN)	participant	0.00
4	FONDAZIONE ANDREA CESALPINO  Organization address address: VIA SICILIA 169 city: ROMA postcode: 197 contact info Titolo: Mr. Nome: Luigino Cognome: Mangiapelo Email: send email Telefono: +39 064453994 Fax: +39 0649383333	IT (ROMA)	participant	0.00
5	FONDAZIONE PER L'ISTITUTO DI RICERC A IN BIOMEDICINA  Organization address address: Via Vincenzo Vela 6 city: BELLINZONA postcode: 6500 contact info Titolo: Ms. Nome: Fosca Cognome: Bognuda Email: send email Telefono: +41 91 820 03 00 Fax: +41 91 820 03 02	CH (BELLINZONA)	participant	0.00
6	ISTITUTO SUPERIORE DI SANITA  Organization address address: Viale Regina Elena 299 city: ROMA postcode: 161 contact info Titolo: Dr. Nome: Rosa Maria Cognome: Martoccia Email: send email Telefono: +39 06 4990 2688 Fax: +39 06 4990 3007	IT (ROMA)	participant	0.00
7	TERVEYDEN JA HYVINVOINNIN LAITOS  Organization address address: MANNERHEIMINTIE 166 city: HELSINKI postcode: 300 contact info Titolo: Mr. Nome: Jaakko Cognome: Penttinen Email: send email Telefono: +358 20 610 8203 Fax: +358 20 610 8225	FI (HELSINKI)	participant	0.00
8	VIEN VE SINH DICH TE TRUNG UONG  Organization address address: YERSIN STREET HAI BA TRUNG 1 city: HANOI postcode: 1000 contact info Titolo: Prof. Nome: Duc Anh Cognome: Dang Email: send email Telefono: 8449712989 Fax: 8448212660	VN (HANOI)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'IMECS is a proposal of the FLUSECURE network aimed at combating the threat of new and re-emerging forms of highly pathogenic influenza in its first stages of a disease by identifying mechanisms of protection that are essential for a solid immune response to avian influenza. IMECS is uniquely featured by correlating research in humans directly to protection from influenza. The IMECS initiative was introduced since the recent H5N1 avian influenza vaccine trials results have shown limited success in inducing a protective immune response as compared to the standard human influenza vaccines. This despite large investments and multiple vaccine formulations tested. These results make clear that the mechanisms of immunity for avian influenza are inherently different from those for human/seasonal influenza. The IMECS initiative aims to elucidate these mechanisms and aims to provide essential knowledge for development of breakthrough pandemic vaccines as a result. The initiative thereto boosts the development of AI-correlates of protection for the clinical screening of vaccine candidates in healthy adults and in different target groups, the origin of subclinical AI infection in humans, as well as a research programme for the screening of vaccine candidates in vitro. The following research objectives are pursued: - Determining the basis of the homologous and non-homologous mechanisms of protection for avian influenza; - Determine the mechanisms of protection in specific target groups, including infants and the elderly; - Determining the AI-specific response after vaccination in clinical trial studies. IMECS combines the knowledge of leading European universities and research centres. The multidisciplinary consortium has the resources, skills and knowledge to realize the objectives of this collaborative research project.The consortium consists of 6 partners and two subcontractors from five different European countries and one disease endemic country (SICA)'

Introduzione (Teaser)

Pandemic influenza remains a global threat, and may have a severe impact on world health and the global economy. Given that large parts of the population lack anti-influenza immunity, it is crucial that we study the protective immune mechanisms at work following vaccination.