CISSTEM

Cis-regulatory logic of the transcriptional control in neural stem cells

Coordinatore	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE    more  Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Dr. Nome: Jean-Stéphane Cognome: Joly Email: send email Telefono: +33 1 69 82 41 88 Fax: +33 1 69 07 05 38
Nazionalità Coordinatore	France [FR]
Sito del progetto	http://www.cisstem.eu/
Totale costo	4˙002˙786 €
EC contributo	2˙984˙169 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-10-01   -   2012-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE  Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Dr. Nome: Jean-Stéphane Cognome: Joly Email: send email Telefono: +33 1 69 82 41 88 Fax: +33 1 69 07 05 38	FR (PARIS CEDEX 07)	coordinator	0.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Michele Cognome: Saumon Email: send email Telefono: 00 33 1 69 82 32 64 Fax: 00 33 1 69 83 33 33	FR (PARIS)	participant	0.00
3	EUROPEAN MOLECULAR BIOLOGY LABORATORY  Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 contact info Titolo: Dr. Nome: Phil Cognome: Irving Email: send email Telefono: 4962210000000 Fax: 4962210000000	DE (HEIDELBERG)	participant	0.00
4	INRA TRANSFERT S.A.  Organization address address: RUE DU DOCTEUR FINLAY 28 city: PARIS postcode: 75015 contact info Titolo: Ms. Nome: Lucie Cognome: Hofmann Email: send email Telefono: 0033 1 55 35 26 48 Fax: 0033 1 55 35 26 46	FR (PARIS)	participant	0.00
5	Karlsruher Institut fuer Technologie  Organization address address: Kaiserstrasse 12 city: Karlsruhe postcode: 76131 contact info Titolo: Ms. Nome: Natascha Cognome: Wallburg Email: send email Telefono: +49 7247 825414 Fax: +49 7247 825403	DE (Karlsruhe)	participant	0.00
6	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Ms. Nome: Michele Cognome: Marron Email: send email Telefono: (44)-20-8816 2275 Fax: (44)-20-8959-4272	UK (SWINDON)	participant	0.00
7	RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG  Organization address address: SEMINARSTRASSE 2 city: HEIDELBERG postcode: 69117 contact info Titolo: Dr. Nome: Laurence Cognome: Ettwiller Email: send email Telefono: 4962210000000 Fax: +49 6221 387-8166	DE (HEIDELBERG)	participant	0.00
8	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Ms. Nome: Liz Cognome: Fay Email: send email Telefono: +44 161 275 7114 Fax: +44 161 275 2445	UK (MANCHESTER)	participant	0.00
9	UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA  Organization address address: PIAZZA DELL'ATENEO NUOVO 1 city: MILANO postcode: IT-20126 contact info Titolo: Dr. Nome: Anastasia Cognome: Sguera Email: send email Telefono: +39 264483573 Fax: +39 264483569	IT (MILANO)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'Neural stem cells (NSCs) have emerged as a major topic in neurobiology. The persistence of multipotent cells in the adult mammalian brain offers a realistic chance for the treatment of neurodegenerative diseases. It is thus crucial to understand NSCs from as many as possible angles (e. g. cellular and molecular biology), in order to better isolate and successfully manipulate them. CISSTEM presents a post-genomic systems biology approach, taking advantage of new computational and experimental tools to address the specification and maintenance of NSCs at the transcriptional/epigenetic level. CISSTEM is designed to unravel the basic principles of gene regulation in NSC, with a focus on cis-regulatory modules (CRMs). To do so we follow a multidisciplinary approach tightly interconnecting computational prediction and experimental validation in vitro and in vivo using different vertebrate models systems. Major intermediate objectives of this project are the prediction of relevant elements and the identification of the temporal, spatial and quantitative activities of predicted conserved regulatory motifs associated with NSC expressed genes. To achieve this goal, CISSTEM will i) Develop computational tools and resources for the in silico identification of CRMs and transcription factor binding sites (TFBSs) ii) Identify genomic regions functionally active in the NSC through direct mapping of DNase I hypersensitivity sites. Putative functional annotation to these sites will be implemented and conduct direct CRM prediction of the identified regions iii) Identify motifs/signatures over-represented in distal elements found around NSC expressed genes iv) Identify the elements acting as transcriptional enhancers and define their pattern of activities in different neural cell lines and in vertebrate animal model systems v) Disseminate the results of the project to the research community, biotech/pharmaceutical companies and the general public'

Introduzione (Teaser)

Better understanding of stem cells is important for regenerative therapy. Identifying which genes are involved in their maintenance and regulation provides the basis for their therapeutic exploitation.