FIGHTMAL

Correlating protection against malaria with serum profiles against Plasmodium falciparum antigen repertoires

Coordinatore	UNIVERSITA DEGLI STUDI DI PERUGIA    more  Organization address address: PIAZZA DELL' UNIVERSITA 1 city: PERUGIA postcode: 6123 contact info Titolo: Prof. Nome: Vincenzo Nicola Cognome: Talesa Email: send email Telefono: +39 0755858222 Fax: +39 0755858415
Nazionalità Coordinatore	Italy [IT]
Totale costo	1˙870˙768 €
EC contributo	1˙870˙768 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-3-1-IAPP
Funding Scheme	MC-IAPP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-06-01   -   2012-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI PERUGIA  Organization address address: PIAZZA DELL' UNIVERSITA 1 city: PERUGIA postcode: 6123 contact info Titolo: Prof. Nome: Vincenzo Nicola Cognome: Talesa Email: send email Telefono: +39 0755858222 Fax: +39 0755858415	IT (PERUGIA)	coordinator	0.00
2	INFECTIOUS DISEASES RESEARCH COLLABORATION LIMITED  Organization address address: NEW MULAGO HILL ROAD city: KAMPALA postcode: 256 contact info Titolo: Ms. Nome: Catherine Cognome: Tugaineyo Email: send email Telefono: +25 6712408950 Fax: 256415000000	UG (KAMPALA)	participant	0.00
3	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE  Organization address address: KEPPEL STREET city: LONDON postcode: WC1E7HT contact info Titolo: Prof. Nome: Eleanor Cognome: Riley Email: send email Telefono: +44 20 79272706 Fax: +44 20 79272807	UK (LONDON)	participant	0.00
4	MED BIOTECH LABORATORIES  Organization address address: "Lugwana Close, Myenga Tank Hill By-Pass" city: KAMPALA postcode: 256 contact info Titolo: Dr. Nome: Thomas Cognome: Egwang Email: send email Telefono: +256 712 627487 Fax: +256 41 510408	UG (KAMPALA)	participant	0.00
5	MICROTEST MATRICES LTD  Organization address address: 14 Prices Gardens city: LONDON postcode: SW7 1NA contact info Titolo: Ms. Nome: Clelia Cognome: Supparo Email: send email Telefono: +44 207 5947999 Fax: +44 207 5947998	UK (LONDON)	participant	0.00
6	PX'Therapeutics  Organization address address: "15, rue des Martyrs" city: GRENOBLE postcode: 38027 contact info Titolo: Dr. Nome: Tristan Cognome: Rousselle Email: send email Telefono: +33 4 38023650 Fax: +33 4 76961038	FR (GRENOBLE)	participant	0.00

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 Obiettivo del progetto (Objective)

'People living in malaria endemic areas develop, with time, a form of immunity to infection and clinical disease mediated by antibodies directed against P. falciparum antigens. Currently there are no assays or clinical parameters that predict whether an exposed person is protected against malaria. This represents a major obstacle for vaccine development. Here research institutions and industrial partners, combining cutting edge expertise in protein microarrays, immunoassay development, immunology, protein expression and epidemiology join their efforts with the objective of translating the genome sequence information of Plasmodium falciparum into a tool to unravel correlates of protection against human malaria. Recombinant P. falciparum proteins, encompassing the repertoire of secreted and surface antigens, will be printed onto microarrays to develop an immunoassay capable of unraveling antibodies directed against a vast number of parasite molecules. This assay will be utilized to compare the antigen-antibody recognition profiles of protected and non-protected persons in malaria-exposed communities, thus facilitating the identification of the antigens that either alone or in combination function as targets of protective immunity. The underlying project structure in terms of research activities, task distribution and management has been planned with the priority of facilitating the interactions of human resources, between academic institutions and industry. Exchange of staff and networking activities will bridge the scientific and cultural differences existing between the academic and industrial partners. Exchange of scientific knowledge and technical skill will unleash the full potential of the collective expertise of the participating laboratories towards the objectives of the proposal and will be instrumental in building collaborative links that will extend beyond the duration of the project.'

Introduzione (Teaser)

The human malaria parasite Plasmodium falciparum is one of the leading causes of death in many countries. The development and implementation of an effective and durable anti-malarial vaccine is a global health priority.