BREATH

Characterization of biomarkers in breath of lung and breast cancer patients

Coordinatore	CONSIGLIO NAZIONALE DELLE RICERCHE    more  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Simone Cognome: Cristoni Email: send email Telefono: -45077601 Fax: -700410215
Nazionalità Coordinatore	Italy [IT]
Totale costo	170˙902 €
EC contributo	170˙902 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-05-01   -   2010-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Dr. Nome: Simone Cognome: Cristoni Email: send email Telefono: -45077601 Fax: -700410215	IT (ROMA)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'Recent studies have noted that dogs are able to identify with high confidence the presence of cancerous tissues in patients at an early stage based on sniffing a breath sample. Because exhaled breath provides non-invasively a continuous window to the biochemical activity within a person, its analysis for medical diagnosis has produced a substantial literature. However, its diagnostic reliability is still incomparable to that of dogs. In fact, breath analysis has not been introduced into common clinical practice yet mainly due to the lack of correlation with high confidence between the presence of certain biomarkers and the illness. Recently, we have shown that widely used commercial atmospheric pressure ionization mass spectrometers (API-MS) can sense breath vapors with molecular masses approaching 450 Da with high signal/background. These findings are in striking contrast with prior breath analysis literature (GC-MS and PTR-MS), involving molecular masses below 290 Da. Our data suggests that dogs have the sensitivity needed to detect such heavy breath vapors, which must be key elements in their cancer recognition process. Urea is one important low volatility biomarker which has not been observed in previous GC-MS and PTR-MS studies, but which we can measure in breath and have been positively identified. In our approach, the subject’s breath is exposed to an electrospray of acidified water, where protonation of polar species takes place near the inlet of an API-MS. The same approach has been successfully used to detect acids (i.e. lactic and pyruvic acids), operating in negative mode. Besides its sensitivity, one main advantage of this approach is that it is on-line and requires no breath sample collection. The main goal of this project is to determine potential biomarkers in breath of breast and lung cancer patients. To do so, we will carry out a systematic survey comparing the breath of healthy subjects and cancer patients.'