LIPIDIDIET
"THERAPEUTIC AND PREVENTIVE IMPACT OF NUTRITIONAL LIPIDS ON NEURONAL AND COGNITIVE PERFORMANCE IN AGING, ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA"
| Coordinatore | UNIVERSITAET DES SAARLANDES
Organization address
address: CAMPUS contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.lipididiet.progressima.eu/ |
| Totale costo | 7˙995˙577 € |
| EC contributo | 5˙899˙843 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2007-1 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-08-01 - 2015-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAET DES SAARLANDES
Organization address
address: CAMPUS contact info |
DE (SAARBRUECKEN) | coordinator | 0.00 |
| 2 |
Nome Ente NON disponibile
Organization address
address: YLIOPISTONRANTA 1 E contact info |
FI (Kuopio) | participant | 0.00 |
| 3 |
DANONE RESEARCH BV
Organization address
address: Bosrandweg 20 contact info |
NL (UTRECHT) | participant | 0.00 |
| 4 |
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Organization address
address: GESCHWISTER-SCHOLL-PLATZ contact info |
DE (TUEBINGEN) | participant | 0.00 |
| 5 |
EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Organization address
address: Science Park 1, Stuhlsatzenhausweg 69 contact info |
DE (SAARBRUECKEN) | participant | 0.00 |
| 6 |
FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (VVI)
Organization address
address: VIDENSKA 1083 contact info |
CZ (PRAHA 4) | participant | 0.00 |
| 7 |
GOETEBORGS UNIVERSITET
Organization address
address: VASAPARKEN contact info |
SE (GOETEBORG) | participant | 0.00 |
| 8 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 0.00 |
| 9 |
KLINIKUM DER UNIVERSITAET REGENSBURG
Organization address
address: FRANZ JOSEF STRAUSS ALLEE 11 contact info |
DE (REGENSBURG) | participant | 0.00 |
| 10 |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address
address: GESCHWISTER SCHOLL PLATZ 1 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 11 |
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Organization address
address: REGINA PACIS WEG 3 contact info |
DE (BONN) | participant | 0.00 |
| 12 |
STICHTING KATHOLIEKE UNIVERSITEIT
Organization address
address: GEERT GROOTEPLEIN NOORD 9 contact info |
NL (NIJMEGEN) | participant | 0.00 |
| 13 |
STICHTING VU-VUMC
Organization address
address: DE BOELELAAN 1105 contact info |
NL (AMSTERDAM) | participant | 0.00 |
| 14 |
SZEGEDI TUDOMANYEGYETEM
Organization address
address: DUGONICS TER 13 contact info |
HU (SZEGED) | participant | 0.00 |
| 15 |
TEL AVIV UNIVERSITY
Organization address
address: RAMAT AVIV contact info |
IL (TEL AVIV) | participant | 0.00 |
| 16 |
UNIVERSITAETSKLINIKUM AACHEN
Organization address
address: Pauwelsstrasse 30 contact info |
DE (AACHEN) | participant | 0.00 |
| 17 |
UNIVERSITAETSKLINIKUM HEIDELBERG
Organization address
address: IM NEUENHEIMER FELD 672 contact info |
DE (HEIDELBERG) | participant | 0.00 |
| 18 |
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Organization address
address: De Boelelaan 1105 contact info |
NL (AMSTERDAM) | participant | 0.00 |
| 19 |
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Organization address
address: Square J 5 contact info |
DE (MANNHEIM) | participant | 0.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'Major objective: It is our aim to develop a lipid based diet that is able to delay or prevent onset of Alzheimer’s disease and related diseases and has a stabilizing effect on cognitive performance in aging. Multiple lines of evidence suggest that there is a large overlap between risk factor of these three diseases. Importantly, there is equally strong evidence that prevention and treatment of these diseases can be efficiently addresses - especially in their first and their priclinical stages - by closely related or identical bio-molecules. Predominantly these molecules appear to belong to the class of lipids which are part of the human diet. However, very often they are consumed in far lesser than recommended amounts. Bearing in mind that all of these diseases have a long pre-clinical phase in which the disease remains undetected specifically designed nutrition may be requirred for effective prevention or for those who already progressed into the first clinical stage of the disease. Moreover, frequently the within the elderly population pathological changes by two or all of these diseases occur in combination thus targeting only one would be insufficient. Taking these aspects into consideration, dietary supplementation, composed to maximize benefit for all three of these in the elderly common diseases, appears to be the most suitable approach to provide a general health perspective improvement for this age group in the EU population.'
Introduzione (Teaser)
The EU-funded LIPIDIDIET project aimed to develop a lipid-based diet capable of delaying or preventing the onset of Alzheimer's disease and vascular dementia. Such a diet would have a stabilising effect on neuronal and cognitive performance in ageing.
Descrizione progetto (Article)
Research and scientific evidence point to a large overlap between the risk factors of these and other related diseases, and indicates that they may be treated and prevented by leveraging the potential of closely related or identical biomolecules. These molecules are thought to belong to the class of lipids that are part of the human diet, but which are all too often consumed in less-than-recommended amounts.
Given that these diseases have a long preclinical phase during which the disease remains undetected, specifically designed nutrition may help prevent further progression. It may also prove useful for those who have already progressed into the first clinical stage.
Dietary supplementation, composed to maximise benefit for pathological changes related to ageing, is thus slated as the most suitable approach for improving on the general health perspective of Europe's elderly population.
Project members have produced a lipid-based diet for the treatment of volunteers in a double-blinded clinical trial, although it is still too early to assess the treatment's effect. However, in all parameters analysed thus far, the trial is performing as expected or better than expected. The parameters include safety/adverse side-effects, compliance, and drop-out rates and variance.
Clinical data based on the study participants reveal that diet-based early intervention significantly increases memory performance. As such, http://www.lipididiet.eu/ (LIPIDIDIET) researchers generally assume that earlier intervention would boost results even further.
To date, they have identified or further detailed dietary, lifestyle and genetic risk factors, as well as combinations of these factors that correlate with a decreased or increased risk for dementia. The researchers have studied the role of neurotransmission and identified novel mechanisms relating to how the dementia-causing amyloid molecules interfere with synaptic transmission, cellular differentiation and function. Progress has also been made on better understanding how dietary lipids might reduce this interference.
LIPIDIDIET results have already contributed to the development of dietary approaches and formulations that aim to more effectively reduce the risk for age-related cognitive decline. Continuing research and empirical study efforts thus offer great possibilities for future approaches to preventing and arresting the development of diseases like Alzheimer's and vascular dementia.