MITIN

INTEGRATION OF THE SYSTEM MODELS OF INSULIN SIGNALLING AND OF MITOCHONDRIAL FUNCTION AND ITS APPLICATION IN THE STUDY OF COMPLEX DISEASES

Coordinatore	FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)    more  Organization address address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA city: BARCELONA postcode: 8028 contact info Titolo: Ms. Nome: Adriana Cognome: Grosu Email: send email Telefono: + 34 93 402 04 50 Fax: +34 93 403 71 14
Nazionalità Coordinatore	Spain [ES]
Totale costo	3˙846˙079 €
EC contributo	2˙956˙490 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-11-01   -   2011-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)  Organization address address: CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA city: BARCELONA postcode: 8028 contact info Titolo: Ms. Nome: Adriana Cognome: Grosu Email: send email Telefono: + 34 93 402 04 50 Fax: +34 93 403 71 14	ES (BARCELONA)	coordinator	0.00
2	BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION  Organization address address: Calle Jordi Girona 31 city: BARCELONA postcode: 8034 contact info Titolo: Ms. Nome: Mercè Cognome: Calvet Email: send email Telefono: + 34 93 413 77 17 Fax: +34 93 413 77 21	ES (BARCELONA)	participant	0.00
3	DEUTSCHES KREBSFORSCHUNGSZENTRUM  Organization address address: Im Neuenheimer Feld 280 city: HEIDELBERG postcode: 69120 contact info Titolo: Ms. Nome: Bettina Cognome: Crispin Email: send email Telefono: +49 6221 42 2700 Fax: +49 6221 42 2708	DE (HEIDELBERG)	participant	0.00
4	TEKNOLOGIAN TUTKIMUSKESKUS VTT  Organization address address: TEKNIIKANTIE 4 A city: ESPOO postcode: 02044 VTT contact info Titolo: Ms. Nome: Katri Cognome: Kokkila Email: send email Telefono: +358 20 722 33 03 Fax: + 358 20 722 33 65	FI (ESPOO)	participant	0.00
5	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Dawn Cognome: Edwards Email: send email Telefono: +44 1223 333543 Fax: +44 1223 332988	UK (CAMBRIDGE)	participant	0.00
6	THE UNIVERSITY OF LIVERPOOL  Organization address address: Brownlow Hill, Foundation Building 765 city: LIVERPOOL postcode: L69 7ZX contact info Titolo: Dr. Nome: Jane Cognome: Cloke Email: send email Telefono: +44 151 794 8726 Fax: +44 151 794 8728	UK (LIVERPOOL)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'A common trait to disorders such as type 2 diabetes or obesity is the development of insulin resistance. There is evidence indicating the existence of a bidirectional cross-talk between insulin signalling and mitochondrial function that may be relevant for the pathogenesis of those disorders. Based on this, MITIN main goal is to identify novel mitochondrial-dependent mechanisms responsible for the development of insulin resistance. This will be done by the use of technologies of Systems Biology and the generation of computer-based tools that will permit the study of complex biological systems that integrate different regulatory networks. For the global visualization and interpretation of the “insulin signalling/mitochondria” complex system we plan to develop a computational framework that will store and integrate all possible data for each of the subsystems, both currently available data and data generated within the project by transcriptomics and lipidomics analysis. This will allow the prediction of functional associations and interactions between both processes, which will be tested under specific hypothesis-driven studies in mammalian cells, mice and Drosophila. By using a Systems Biology approach and investigating how different perturbations modulate cell transcriptomes, and lipidomes, we aim to identify integrated homeostatic responses involving the insulin signalling network and the mitochondria networks. Validation of some of the strongest associations detected by virtue of the integrated systems biology of insulin signalling/mitochondria will generate high value targets of use in therapy against Complex Diseases such as diabetes, obesity, or pathophysiological traits of the Metabolic Syndrome. Besides, computer-based tools generated in the project will be applicable to the analysis of the mechanisms that trigger other Complex Diseases.'

Introduzione (Teaser)

A European consortium developed a computational framework enabling them to predict functional associations and interactions between insulin signalling and mitochondrial processes. Results led to the identification of novel genes of potential clinical relevance.