ROS IN INFLAMMATION

Characterization of Reactive Oxygen Species as Innate Immune System Mediators that Control Inflammation

Coordinatore	GOETEBORGS UNIVERSITET    more  Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 contact info Titolo: Dr. Nome: Ludde Cognome: Edgren Email: send email Telefono: -7862768 Fax: -7864340
Nazionalità Coordinatore	Sweden [SE]
Totale costo	178˙454 €
EC contributo	178˙454 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-4-2-IIF
Funding Scheme	MC-IIF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2011-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	GOETEBORGS UNIVERSITET  Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 contact info Titolo: Dr. Nome: Ludde Cognome: Edgren Email: send email Telefono: -7862768 Fax: -7864340	SE (GOETEBORG)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'Biomedical research in the post genomic era will depend on the establishment of collaborative efforts between clinical and preclinical researchers, combining bedside medical research with experimental science. This project stems from initial gene expression studies on immune compromised patients with severe inflammatory disorders. The results allowed us to generate the hypothesis that reactive oxygen radicals are key anti-inflammatory agents in the immune system. We also embrace the novel idea that it is possible to stimulate an innate immune response without exciting harmful inflammation and moreover, that it is possible to identify molecular regulators as potential therapeutic targets that allow such an immune response. The proposed project will be multidisciplinary, incorporating old and new technologies in both the wet and dry lab environments that combine aspects of immunology, cell biology, bioinformatics and clinical microbiology. It will constitute the first comprehensive study of the role of oxygen radicals in inflammation and immunity outside the traditionally described roles of radicals in oxidative microbial killing and neutrophil apoptosis. In addition, it will highlight a novel set of immune regulators with therapeutic potential and provide a template for future biology-based drug discovery platforms that originate in the clinic.'