BAR STRUCTURE

Microcrystallography of stabilized adrenergic receptors

Coordinatore	MEDICAL RESEARCH COUNCIL    more  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Ms. Nome: Elizabeth Cognome: Cutler Email: send email Telefono: +44-(0)1223 402357 Fax: +44-(0) 1223 452515
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	178˙874 €
EC contributo	178˙874 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2010-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Ms. Nome: Elizabeth Cognome: Cutler Email: send email Telefono: +44-(0)1223 402357 Fax: +44-(0) 1223 452515	UK (SWINDON)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'Nowadays microfocus beamlines at intense and brilliant synchrotron radiation sources allow studies of samples with low X-ray scattering power to be curried out with new micro-methods. Structural information of excellent quality can be produced for proteins, which crystallize yielding only tiny crystals. The structure of recombinant rhodopsin obtained recently in host laboratory is an example of successful microcrystallography application. Several other membrane proteins from the GPCR family were studied in host laboratory for many years among them adrenergic receptors. Recently microcrystals of beta-adrenergic receptor were obtained in host laboratory and structure solution efforts were initiated. The corresponding strategy for structure solution of beta-adrenergic receptor is proposed here. New approaches to data collection from microcrystals including scanning microdiffraction and random data collection will be developed for successful structure determination. Application of micron and sub-micron beams for data collection will be assessed. Additionally, development of the software dedicated for reduction of data from microcrystals is suggested. Efforts in advancing microcrystallography will result in obtaining a high-resolution structure of beta-adrenergic receptor, which will help to rational drug design and will give new insights on GPCR signalling mechanism.'