SYSINBIO
Systems Biology as a Driver for Industrial Biotechnology
| Coordinatore | CHALMERS TEKNISKA HOEGSKOLA AB
Organization address
address: - contact info |
| Nazionalità Coordinatore | Sweden [SE] |
| Sito del progetto | http://www.sysbio.se/SYSINBIO |
| Totale costo | 1˙485˙204 € |
| EC contributo | 996˙545 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2007-1 |
| Funding Scheme | CSA-CA |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-12-01 - 2011-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CHALMERS TEKNISKA HOEGSKOLA AB
Organization address
address: - contact info |
SE (GOETEBORG) | coordinator | 0.00 |
| 2 |
BASF SE
Organization address
address: CARL BOSCH STRASSE 38 contact info |
DE (LUDWIGSHAFEN AM RHEIN) | participant | 0.00 |
| 3 |
BOGAZICI UNIVERSITESI
Organization address
address: BEBEK contact info |
TR (ISTANBUL) | participant | 0.00 |
| 4 |
CHR. HANSEN A/S
Organization address
address: Boege Alle 10-12 contact info |
DK (HOERSHOLM) | participant | 0.00 |
| 5 |
DANMARKS TEKNISKE UNIVERSITET
Organization address
address: Anker Engelundsvej 1, Building 101A contact info |
DK (KONGENS LYNGBY) | participant | 0.00 |
| 6 |
DSM FOOD SPECIALTIES BV
Organization address
address: ALEXANDER FLEMINGLAAN 1 contact info |
NL (DELFT) | participant | 0.00 |
| 7 |
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Organization address
address: BATIMENT CE 3316 STATION 1 contact info |
CH (LAUSANNE) | participant | 0.00 |
| 8 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
CH (ZUERICH) | participant | 0.00 |
| 9 |
EVONIK DEGUSSA GmbH
Organization address
address: Rellinghauser Str. 1-11 contact info |
DE (Essen) | participant | 0.00 |
| 10 |
FLUXOME SCIENCES A/S
Organization address
address: GYMNASIEVEJ 5 contact info |
DK (STENLOSE) | participant | 0.00 |
| 11 |
LUNDS UNIVERSITET
Organization address
address: Paradisgatan 5c contact info |
SE (LUND) | participant | 0.00 |
| 12 |
METABOLIC EXPLORER SA
Organization address
address: BIOPOLE CLERMONT LIMAGNE contact info |
FR (SAINT BEAUZIRE) | participant | 0.00 |
| 13 |
NOVOZYMES A/S
Organization address
address: Krogshoejvej 36 contact info |
DK (BAGSVAERD) | participant | 0.00 |
| 14 |
STIFTELSEN FRAUNHOFER-CHALMERS CENTRUM FOR INDUSTRIMATEMATIK
Organization address
address: Chalmers Science Park contact info |
SE (GOETEBORG) | participant | 0.00 |
| 15 |
TECHNISCHE UNIVERSITEIT DELFT
Organization address
address: Stevinweg 1 contact info |
NL (DELFT) | participant | 0.00 |
| 16 |
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Organization address
address: TEKNIIKANTIE 4 A contact info |
FI (ESPOO) | participant | 0.00 |
| 17 |
UNIVERSIDADE DO MINHO
Organization address
address: Largo do Paco contact info |
PT (BRAGA) | participant | 0.00 |
| 18 |
UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Organization address
address: PIAZZA DELL'ATENEO NUOVO 1 contact info |
IT (MILANO) | participant | 0.00 |
| 19 |
UNIVERSITAET DES SAARLANDES
Organization address
address: CAMPUS contact info |
DE (SAARBRUECKEN) | participant | 0.00 |
| 20 |
UNIVERSITAET SIEGEN
Organization address
address: HERRENGARTEN 3 contact info |
DE (SIEGEN) | participant | 0.00 |
| 21 |
UNIVERSITAET STUTTGART
Organization address
address: Keplerstrasse 7 contact info |
DE (STUTTGART) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'Metabolic engineering is an applied science focusing on developing new cell factories or improving existing ones. Metabolic engineering is an enabling science, and distinguishes itself from applied genetic engineering by the use of advanced analytical tools for identification of appropriate targets for genetic modifications and the use of mathematical models to perform in silico design of optimized cell factories. In recent years, there has been increasing focus on using mathematical models for design. SYSIBIO will coordinate European activities in the field of model driven metabolic engineering and also coordination of activities on other technologies required for state of the art metabolic engineering, e.g. metabolomics and fluxomics. The coordination of activities will involve establishing a database containing metabolic models for different industrially important microorganisms. The database will also contain different simulation tools required for use of these models to identify metabolic engineering targets and use of these models for analysis of omics data. SYSINBIO will also coordinate the further development of techniques required for metabolic engineering, such as metabolomics, fluxomics and identification of mutations in evolved strains. Furthermore, an important part of SYSINBIO will be coordination of education and training in the field of metabolic engineering in Europe.'
Introduzione (Teaser)
One day soon metabolic engineering could revolutionise the chemical industry. To push Europe to the forefront of the technology, an EU-funded project is coordinating research activities.
Descrizione progetto (Article)
Metabolic engineering is the practice of optimising genetic and regulatory processes within cells to increase the cells' production of a certain substance. It is an applied science focusing on either developing new cell factories or improving existing ones. It uses advanced analytical tools to identify appropriate targets for genetic modifications and mathematical models to perform in silico design of optimised cell factories used in industrial biotechnology.
With the focus on using mathematical models for design increasing in recent years, the EU-funded 'Systems biology as a driver for industrial biotechnology' (Sysinbio) project is now coordinating European efforts. Sysinbio's lead role in Europe's model-driven metabolic engineering activities has led to the creation of the BioMet ToolBox database. This contains metabolic models for different, industrially important micro-organisms and various simulation tools.
Sysinbio is currently developing new and better mathematical models of metabolism that can be used for metabolic engineering. Activities on both stoichiometric (of reactants) models and kinetic (energy produced by motion) models have already been coordinated.
So far, the project team has shown that coordination of the development of more reliable and standardised microbial models has enhanced model predictions. This has enabled the application of simulation and optimisation algorithms that can identify gene modifications that can increase the production yields of target compounds.
Another important part of Sysinbio has been the coordination of education and training in the field of metabolic engineering in Europe. This has resulted in support for students participating at key conferences and the organisation of various dedicated courses on systems biology.
The project results are expected to have a significant long-term impact on improving the competiveness of European industrial biotechnology. Benefits will include improved dialogue between academia and industry, better training for researchers, and the provision of enhanced standards and methods for use in industrial biotechnology.