LIGHTSWITCHES

Multifunctional DNA light-switches: sensors and devices

Coordinatore	THE UNIVERSITY OF SHEFFIELD    more  Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: -2221504 Fax: -2221525
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	169˙957 €
EC contributo	169˙957 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-4-2-IIF
Funding Scheme	MC-IIF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-04-20   -   2011-04-19

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF SHEFFIELD  Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: -2221504 Fax: -2221525	UK (SHEFFIELD)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'Photoactive mono- and oligonuclear transition metal complexes containing DNA intercalative ligands will be synthesized. In the latter case, both homo- and heterometallic complexes will be synthesized. The photophysical properties of the complexes will be exploited to produce a number of outcomes: prototypical sensors for DNA sequences and/or structures that will produce a luminescent output on DNA binding, tools for investigating DNA/substrate binding events and the photophysical/electronic properties of DNA. The synthesis of multi-functional probes will also be investigated; e.g. DNA light-switches that also cleave DNA (directly OR through singlet oxygen sensitizing) and/or display cytotoxicity. To fully understand the properties of the new systems and their interaction with DNA studies will encompass a wide spectrum of techniques from time resolved optical spectroscopy, to calorimetry and in cellulo studies.'