CADASTER

CAse studies on the Development and Application of in-Silico Techniques for Environmental hazard and Risk assessment

Coordinatore	RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN    more  Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA contact info Titolo: Prof. Nome: Willie Cognome: Peijnenburg Email: send email Telefono: 31302743129 Fax: 31302744413
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	3˙394˙000 €
EC contributo	2˙692˙034 €
Programma	FP7-ENVIRONMENT Specific Programme "Cooperation": Environment (including Climate Change)
Code Call	FP7-ENV-2007-1
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2012-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN  Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA contact info Titolo: Prof. Nome: Willie Cognome: Peijnenburg Email: send email Telefono: 31302743129 Fax: 31302744413	NL (BILTHOVEN)	coordinator	550˙201.00
2	LINNEUNIVERSITETET  Organization address address: LINNAEUS UNIVERSITY city: VAXJO postcode: 35195 contact info Titolo: Ms. Nome: Johanna Cognome: Egerup Email: send email Telefono: +46 480447348 Fax: +46 480447381	SE (VAXJO)	participant	366˙150.00
3	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Jürgen Cognome: Ertel Email: send email Telefono: +49 89 3187 3022 Fax: +49 89 3187 3866	DE (MUENCHEN)	participant	362˙375.00
4	ZAVOD ZA ZDRAVSTVENO VARSTVO MARIBOR  Organization address address: PRVOMAJSKA 1 1 city: MARIBOR postcode: 2000 contact info Titolo: Mr. Nome: Ales Cognome: Gutmaher Email: send email Telefono: 38624602355 Fax: 38624500227	SI (MARIBOR)	participant	333˙768.00
5	STICHTING KATHOLIEKE UNIVERSITEIT  Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ contact info Titolo: Dr. Nome: Mark Cognome: Huijbregts Email: send email Telefono: +31 24 3652835 Fax: +31 24 3653030	NL (NIJMEGEN)	participant	321˙100.00
6	IVL SVENSKA MILJOEINSTITUTET AB  Organization address address: Valhallavaegen 81 city: STOCKHOLM postcode: 100 31 contact info Titolo: Dr. Nome: Magnus Cognome: Rahmberg Email: send email Telefono: +46 8 59856391 Fax: +46 8 59856390	SE (STOCKHOLM)	participant	308˙150.00
7	UNIVERSITA DEGLI STUDI DELL'INSUBRIA  Organization address address: Via Ravasi 2 city: VARESE postcode: 21100 contact info Titolo: Ms. Nome: Adriana Cognome: Jacona Email: send email Telefono: +39 0332 421392 Fax: +39 0332421330	IT (VARESE)	participant	285˙750.00
8	IDEACONSULT LIMITED LIABILITY COMPANY  Organization address address: ANGEL KANCHEV 4 city: SOFIA postcode: 1000 contact info Titolo: Dr. Nome: Luben Cognome: Boyanov Email: send email Telefono: +359 885852486 Fax: +359 29526265	BG (SOFIA)	participant	127˙040.00
9	MIKE COMBER CONSULTING SPRL  Organization address address: SQUARE PREVOST DELAUNAY 123 city: BRUXELLES postcode: 1030 contact info Titolo: Dr. Nome: Mike Cognome: Comber Email: send email Telefono: 3222416099 Fax: 3222416099	BE (BRUXELLES)	participant	37˙500.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Implementation of REACH requires demonstration of the safe manufacture and use of chemicals. REACH aims to achieve a proper balance between societal, economic and environmental objectives, and attempts to efficiently use the scarce and scattered information available on the majority of substances. Thereupon REACH aims to reduce animal testing by optimized use of in silico and in vitro information on related compounds. The REACH proposals advocate the use of non-animal testing methods, but guidance is needed on how these methods should be used. The procedures include alternative methods such as chemical and biological read-across, in vitro results, in vivo information on analogues, (Q)SARs, and exposure-based waiving. The concept of Intelligent Testing Strategies for regulatory endpoints has been outlined to facilitate the assessments. Intensive efforts are needed to translate the concept into a workable, consensually acceptable, and scientifically sound strategy. CADASTER aims at providing the practical guidance to integrated risk assessment by carrying out a full hazard and risk assessment for chemicals belonging to four compound classes. A DSS will be developed that will be updated on a regular basis in order to accommodate and integrate the alternative methods mentioned above. Operational procedures will be developed, tested, and disseminated that guide a transparent evaluation of four classes of emerging chemicals, explicitly taking account of variability and uncertainty in data and in models. The main goal is to exemplify the integration of information, models and strategies for carrying out safety-, hazard- and risk assessments for large numbers of substances. Real risk estimates will be delivered according to the basic philosophy of REACH of minimizing animal testing, costs, and time. CADASTER will show how to increase the use of non-testing information for regulatory decision whilst meeting the main challenge of quantifying and reducing uncertainty.'

Introduzione (Teaser)

Rigorous safety and regulatory standards require expensive, time-consuming and extensive animal testing to obtain approval for the commercial manufacture of chemicals. The EU-funded CADASTER project has devised viable cheaper alternatives to minimise animal testing.