CADASTER
CAse studies on the Development and Application of in-Silico Techniques for Environmental hazard and Risk assessment
| Coordinatore | RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN
Organization address
address: Antonie Van Leeuwenhoeklaan 9 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 3˙394˙000 € |
| EC contributo | 2˙692˙034 € |
| Programma | FP7-ENVIRONMENT
Specific Programme "Cooperation": Environment (including Climate Change) |
| Code Call | FP7-ENV-2007-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-01-01 - 2012-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN
Organization address
address: Antonie Van Leeuwenhoeklaan 9 contact info |
NL (BILTHOVEN) | coordinator | 550˙201.00 |
| 2 |
LINNEUNIVERSITETET
Organization address
address: LINNAEUS UNIVERSITY contact info |
SE (VAXJO) | participant | 366˙150.00 |
| 3 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
DE (MUENCHEN) | participant | 362˙375.00 |
| 4 |
ZAVOD ZA ZDRAVSTVENO VARSTVO MARIBOR
Organization address
address: PRVOMAJSKA 1 1 contact info |
SI (MARIBOR) | participant | 333˙768.00 |
| 5 |
STICHTING KATHOLIEKE UNIVERSITEIT
Organization address
address: GEERT GROOTEPLEIN NOORD 9 contact info |
NL (NIJMEGEN) | participant | 321˙100.00 |
| 6 |
IVL SVENSKA MILJOEINSTITUTET AB
Organization address
address: Valhallavaegen 81 contact info |
SE (STOCKHOLM) | participant | 308˙150.00 |
| 7 |
UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Organization address
address: Via Ravasi 2 contact info |
IT (VARESE) | participant | 285˙750.00 |
| 8 |
IDEACONSULT LIMITED LIABILITY COMPANY
Organization address
address: ANGEL KANCHEV 4 contact info |
BG (SOFIA) | participant | 127˙040.00 |
| 9 |
MIKE COMBER CONSULTING SPRL
Organization address
address: SQUARE PREVOST DELAUNAY 123 contact info |
BE (BRUXELLES) | participant | 37˙500.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'Implementation of REACH requires demonstration of the safe manufacture and use of chemicals. REACH aims to achieve a proper balance between societal, economic and environmental objectives, and attempts to efficiently use the scarce and scattered information available on the majority of substances. Thereupon REACH aims to reduce animal testing by optimized use of in silico and in vitro information on related compounds. The REACH proposals advocate the use of non-animal testing methods, but guidance is needed on how these methods should be used. The procedures include alternative methods such as chemical and biological read-across, in vitro results, in vivo information on analogues, (Q)SARs, and exposure-based waiving. The concept of Intelligent Testing Strategies for regulatory endpoints has been outlined to facilitate the assessments. Intensive efforts are needed to translate the concept into a workable, consensually acceptable, and scientifically sound strategy. CADASTER aims at providing the practical guidance to integrated risk assessment by carrying out a full hazard and risk assessment for chemicals belonging to four compound classes. A DSS will be developed that will be updated on a regular basis in order to accommodate and integrate the alternative methods mentioned above. Operational procedures will be developed, tested, and disseminated that guide a transparent evaluation of four classes of emerging chemicals, explicitly taking account of variability and uncertainty in data and in models. The main goal is to exemplify the integration of information, models and strategies for carrying out safety-, hazard- and risk assessments for large numbers of substances. Real risk estimates will be delivered according to the basic philosophy of REACH of minimizing animal testing, costs, and time. CADASTER will show how to increase the use of non-testing information for regulatory decision whilst meeting the main challenge of quantifying and reducing uncertainty.'
Introduzione (Teaser)
Rigorous safety and regulatory standards require expensive, time-consuming and extensive animal testing to obtain approval for the commercial manufacture of chemicals. The EU-funded CADASTER project has devised viable cheaper alternatives to minimise animal testing.