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MASTERSWITCH

Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices

Coordinatore	ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: Albinusdreef 2 city: LEIDEN postcode: 2333 ZA contact info Titolo: Ms. Nome: Joyce Cognome: Kuijper Email: send email Telefono: 31715263598 Fax: 31715266752
Nazionalità Coordinatore	Netherlands [NL]
Sito del progetto	http://www.masterswitchproject.eu/
Totale costo	14˙805˙808 €
EC contributo	11˙235˙980 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-IP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-12-01 - 2013-11-30

Partecipanti

#	participant	country	role	EC contrib. [€]
1	ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: Albinusdreef 2 city: LEIDEN postcode: 2333 ZA contact info Titolo: Ms. Nome: Joyce Cognome: Kuijper Email: send email Telefono: 31715263598 Fax: 31715266752	NL (LEIDEN)	coordinator	2˙312˙612.00
2	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Jill Cognome: Blomstrand Email: send email Telefono: 46852487687 Fax: 468304452	SE (STOCKHOLM)	participant	1˙178˙912.00
3	BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING Organization address address: Al. Fleming Street 34 city: VARI-ATHENS postcode: 16672 contact info Titolo: Dr. Nome: George Cognome: Kollias Email: send email Telefono: +30 210 965607 Fax: +30 210 9656507	EL (VARI-ATHENS)	participant	944˙480.00
4	MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 contact info Titolo: Prof. Nome: Josef Cognome: Smolen Email: send email Telefono: +43 1 40400 4301 Fax: +43 1 40400 4331	AT (WIEN)	participant	806˙200.00
5	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Ms. Nome: Béatrice Cognome: Saint-Cricq Email: send email Telefono: +33 491164008 Fax: +33 491779340	FR (PARIS)	participant	695˙000.00
6	UNIVERSITAET ZUERICH Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Prof. Nome: Steffen Cognome: Gay Email: send email Telefono: +41 44 255 5737 Fax: +41 442554170	CH (ZURICH)	participant	675˙000.00
7	UNIVERSITY OF LEEDS Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT contact info Titolo: Ms. Nome: Kathy Cognome: Brownridge Email: send email Telefono: +44 113 3436050 Fax: +44 113 3434058	UK (LEEDS)	participant	607˙705.20
8	FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN NURNBERG Organization address address: SCHLOSSPLATZ 4 city: ERLANGEN postcode: 91054 contact info Titolo: Ms. Nome: Ulrike Cognome: Herrmann Email: send email Telefono: +49 9131 85 24043 Fax: +49 9131 85 26239	DE (ERLANGEN)	participant	501˙444.00
9	UNIVERSITAET ZU KOELN Organization address address: ALBERTUS MAGNUS PLATZ city: KOELN postcode: 50923 contact info Titolo: Ms. Nome: Petra Cognome: Schreiner-Kaub Email: send email Telefono: +49 221 4705265 Fax: +49 221 4705265	DE (KOELN)	participant	500˙000.00
10	UNIVERSITY OF GLASGOW Organization address address: University Avenue city: GLASGOW postcode: G12 8QQ contact info Titolo: Mr. Nome: Derek Cognome: Motherwell Email: send email Telefono: +44 141 330 8739 Fax: +44 141 330 2737	UK (GLASGOW)	participant	423˙828.00
11	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Ms. Nome: Ma Del Mar Cognome: Garcia Email: send email Telefono: +34 91585 4984 Fax: +34 914113077	ES (MADRID)	participant	415˙512.00
12	BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNASKAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS Organization address address: ALEXANDER FLEMING STREET 34 city: VARI postcode: 16672 contact info Titolo: Dr. Nome: Nassos Cognome: Alevizopoulos Email: send email Telefono: +30 210 965 5366 Fax: +30 210 965 4621	EL (VARI)	participant	412˙500.00
13	MaimoniDex (UK) Ltd Organization address address: "ONE LONDON WALL, 6TH FLOOR" city: LONDON postcode: EC2Y 5EB contact info Titolo: Dr. Nome: Itshak Cognome: Golan Email: send email Telefono: +44 1972602500 Fax: +44 1792513713	UK (LONDON)	participant	412˙500.00
14	HYBRIGENICS SA Organization address address: IMPASSE REILLE 3-5 city: PARIS postcode: 75014 contact info Titolo: Mr. Nome: Eric Cognome: Cohen Email: send email Telefono: +33 0 158103800 Fax: +33 0 158103840	FR (PARIS)	participant	411˙527.00
15	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Linda Cognome: Pialek Email: send email Telefono: +44 1865289800 Fax: +44 1865289801	UK (OXFORD)	participant	225˙000.00
16	CRANFIELD UNIVERSITY Organization address address: College Road city: CRANFIELD - BEDFORDSHIRE postcode: MK43 0AL contact info Titolo: Mr. Nome: Martin Cognome: Ellis Email: send email Telefono: +44 01234758352 Fax: +44 01234750972	UK (CRANFIELD - BEDFORDSHIRE)	participant	210˙000.80
17	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Julie Cognome: Williams Email: send email Telefono: +44 207 351 8168 Fax: +44 207 351 8277	UK (LONDON)	participant	170˙010.00
18	Redoxis AB Organization address address: MEDICINAREGATAN 8A SAHLGRENSKA SCIENCE PARK city: GOTEBORG postcode: 41346 contact info Titolo: Dr. Nome: Peter Cognome: Olofsson Email: send email Telefono: 46709164608	SE (GOTEBORG)	participant	150˙000.00
19	KING'S COLLEGE LONDON Organization address address: Strand city: LONDON postcode: WC2R 2LS contact info Titolo: Mr. Nome: Paul Cognome: Labbett Email: send email Telefono: +44 2078488184 Fax: +44 2078488187	UK (LONDON)	participant	121˙874.64
20	UNIVERSITY OF SUSSEX Organization address address: Sussex House city: FALMER, BRIGHTON postcode: BN1 9RH contact info Titolo: Mr. Nome: Julian Cognome: Golland Email: send email Telefono: +44 1273678192 Fax: +44 1273678192	UK (FALMER, BRIGHTON)	participant	61˙874.40

Mappa

Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

inflammatory arthritis molecular persistency clinical translational chronicity inflammation anti therapy prevent disease delineate basic biological diagnosis chronic interventions ra rheumatoid drive therapies

Obiettivo del progetto (Objective)

'Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The first generation of targeted therapies in chronic inflammatory disease used RA as prototype disease for clinical development. These therapies are now also used in other inflammatory disorders. Although treatments have been developed that are effective in a proportion of patients, they are aspecific, relatively toxic and do not mediate cure. Currently, it is unknown which molecular effects need to be induced and/or targeted to prevent induction or persistency of RA. However, this is within reach through a strong international consortium of world-leading European groups that cover both basic- and translational research. Work plan: The general strategy for the project is to enable parallel studies that are focussed on critical switch moments in the biological processes that drive chronicity of inflammation. As the consortium consists of a multidisciplinary team with basic- and clinical expertise, translational research will be conducted to delineate the molecular basis of dysregulated inflammation, the RA-specific autoimmune-response and organ specific pathobiology. The final aim is to develop novel- and specific anti-inflammatory therapies. Impact of the project: This project will (i) identify the molecular networks underlying chronic inflammation and thereby (ii) will define novel targets for drug-development as well as (iii) algorithms that will predict outcome of therapy. Moreover, within this project European SMEs will evaluate new interventions (iv) and this project will (v) offer a platform to rapidly develop ideas and patents into new therapies.'

Introduzione (Teaser)

Chronic joint inflammatory diseases like rheumatoid arthritis (RA) are incurable but early diagnosis and therapy can alleviate symptoms. EU-funded researchers studied RA initiation and progression for early diagnosis and effective therapy.