NETSIM
"An integrated study on three novel regulatory hubs in megakaryocytes and platelets, discovered as risk genes for myocardial infarction by a genome-wide association and platelet systems biology study"
| Coordinatore | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 2˙851˙384 € |
| EC contributo | 2˙851˙384 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2007-1-1-ITN |
| Funding Scheme | MC-ITN |
| Anno di inizio | 2008 |
| Periodo (anno-mese-giorno) | 2008-09-01 - 2012-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | coordinator | 0.00 |
| 2 |
Academisch Medisch Centrum bij de Universiteit van Amsterdam
Organization address
address: MEIBERGDREEF 9 contact info |
NL (AMSTERDAM) | participant | 0.00 |
| 3 |
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Organization address
address: Meyerhofstrasse 1 contact info |
DE (HEIDELBERG) | participant | 0.00 |
| 4 |
GENOME RESEARCH LIMITED
Organization address
address: THE GIBBS BUILDING, EUSTON ROAD 215 contact info |
UK (LONDON) | participant | 0.00 |
| 5 |
MEDICAL RESEARCH COUNCIL
Organization address
address: NORTH STAR AVENUE POLARIS HOUSE contact info |
UK (SWINDON) | participant | 0.00 |
| 6 |
ROBERT BOSCH GMBH
Organization address
address: Robert-Bosch Platz 1 contact info |
DE (GERLINGEN-SCHILLERHOEHE) | participant | 0.00 |
| 7 |
SYLVIA LAWRY CENTRE FOR MULTIPLE SCLEROSIS RESEARCH E.V.
Organization address
address: HOHENLINDENER STRASSE 1 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 8 |
TECHNISCHE UNIVERSITAET MUENCHEN
Organization address
address: Arcisstrasse 21 contact info |
DE (MUENCHEN) | participant | 0.00 |
| 9 |
TRIUM ANALYSIS ONLINE GMBH
Organization address
address: HOHENLINDENER STRASSE 1 contact info |
DE (MUNCHEN) | participant | 0.00 |
| 10 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Organization address
address: BELFIELD contact info |
IE (DUBLIN) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'The overarching objective of the ITN is to offer an intercalated study environment for young and talented researchers in the field of coronary artery disease (CAD) research. 12 PhD fellows operating in a unique training environment will work as a multi-disciplinary team to perform research spanning the full spectrum from basic to translational to bring novel inventions to the bedside. The fellows will be mentored by world-leading experts to shape a new generation of European leaders in biomedical science and overcome current fragmentation in Europe. The research is at the forefront of biomedical science because of the UK genome-wide association study in 2000 myocardial infarction (MI) patients and our EU-FP6 integrated projects Bloodomics and Cardiogenics. We will exploit our knowledge about the genetic architecture of MI to investigate the hypothesis whether sequence variation of genes encoding network hubs poses a greater risk for network destabilisation compared to genes encoding regular nodes. Focusing on three hub genes we postulate that genetic/bio-markers associated with hubs can be integrated in algorithms for MI/CAD risk prediction. Success will critically depend on new developments in computing, machine learning, pattern recognition and advanced data mining and statistical analysis. To have a free development path from basic discovery to health care improvement young scientists must be taught to cross the classic barriers between academic disciplines. We offer a timely and necessary alternative to Europe’s classic PhD programmes by providing a seamlessly integrated multi-disciplinary environment in an academic-private sector partnership free of boundaries. Our aim is a targeted strategy for prevention and treatment based on a better understanding of the genetic and molecular mechanism of disease. This will deliver major advances in public health and patient care, which can only be achieved if a new scientific cadre is developed.'
Introduzione (Teaser)
Young scientists have analysed genetic markers, biomarkers and lifestyle risk factors behind the formation of internal blood clots, a feature seen in cardiovascular disease.