SENSORY NEURONS CODE

Defining the transcription factors code directing sensory lineage diversification and connectivity

Coordinatore	KAROLINSKA INSTITUTET    more  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Jill Cognome: Blomstrand Email: send email Telefono: +46 8 524 876 87 Fax: +46 8 30 44 52
Nazionalità Coordinatore	Sweden [SE]
Totale costo	178˙454 €
EC contributo	178˙454 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-1-IEF
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-02-02   -   2010-09-01

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Jill Cognome: Blomstrand Email: send email Telefono: +46 8 524 876 87 Fax: +46 8 30 44 52	SE (STOCKHOLM)	coordinator	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'How is the enormous cellular complexity that characterizes the vertebrate organism arising? Cell diversification depends on the coordinated deployment of multiple programs of cell commitment. One fundamental question is how a discrete number of transcriptional programs combine to produce different cell types. This research aims to address the principles of how cellular diversity is created in the sensory nervous system. Specific objectives: #1:Defining the role of Cux1/2 transcription factors in sensory neuron subtype specification. #2: Defining the role of Cux1/2 in the establishment of specific contacts in the CNS. #3: Identifying potential interactions between Cux and other transcription factors driving diversification. Methods: We propose multidisciplinary approaches including model systems and methods such as rapid assessment of gene function in the chick, peripheral neural stem cell cultures, biochemistry, advanced mouse genetics. Significance and contribution to community: Dysfunction of sensory neurons is associated with a number of diseases lacking adequate treatment (chronic pain, irritable bowel disease, gastro oesophageal reflux disease). This is due to a lack of knowledge in the molecular and functional properties of the subpopulations of sensory neurons. Understanding the molecular mechanisms controlling sensory neurons development is necessary to understand the ontogeny of diseases and may open for new strategies for treatment. Objectives of the action: My goal is to perform research at the international top level and to develop my skills to become a good research group leader. This Marie Curie Fellowship will be highly important for my future scientific carrier. It will allow me to diversify my competence methodologically, to gain new expert knowledge in sensory biology, and to further my career in one of the best neuroscience centers in Europe'