PHENOSCALE

"Large-scale, high-throughput automated systems for phenotyping mouse models of human disease"

Coordinatore	MEDICAL RESEARCH COUNCIL    more  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Dr. Nome: Hilary Cognome: Gates Email: send email Telefono: +44 1235 841252 Fax: +44 1235 841169
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	3˙984˙135 €
EC contributo	2˙999˙461 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-TP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-03-01   -   2012-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Dr. Nome: Hilary Cognome: Gates Email: send email Telefono: +44 1235 841252 Fax: +44 1235 841169	UK (SWINDON)	coordinator	775˙541.00
2	TSE SYSTEMS GMBH  Organization address address: SIEMENSTRASSE 21 city: BAD HOMBURG VOR DER HOHE postcode: 61352 contact info Titolo: Dr. Nome: Hans-Peter Cognome: Engler Email: send email Telefono: -7362 Fax: -7462	DE (BAD HOMBURG VOR DER HOHE)	participant	1˙200˙025.00
3	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Juergen Cognome: Ertel Email: send email Telefono: -6249 Fax: -7093	DE (MUENCHEN)	participant	499˙998.00
4	CONSIGLIO NAZIONALE DELLE RICERCHE  Organization address address: Piazzale Aldo Moro 7 city: ROMA postcode: 185 contact info Titolo: Prof. Nome: Glauco Pasquale Cognome: Tocchini-Valentini Email: send email Telefono: -69060278 Fax: -690091222	IT (ROMA)	participant	499˙500.00
5	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA  Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 contact info Titolo: Mr. Nome: Gabriele Cognome: Ballero Email: send email Telefono: 3901070000000 Fax: 39010720321	IT (GENOVA)	participant	24˙397.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'We are now entering an era of genomic exploration. The mouse is a pre-eminent model not only to map all mammalian genes, but to determine the function of each of these genes. There are now many large-scale projects to create collections of mutant and knock-out mice. However the next step which will add immense value to these collections will be the determination of the phenotype of each of these models. This will be an immense effort and will require input from laboratories and mouse phenotyping centres across the world. For the phenotype to be comparable across strains and between centres, it needs to be determined using standard protocols or SOPs, such as those contained in the European Mouse Phenotyping Resource of Standardised Screens (EMPReSS - www.empress.har.mrc.ac.uk). The goal of PhenoScale is to automate phenotyping in large-scale phenotyping using EMPReSS protocols; with the aim of adding economies of scale, enhancing automated data capture and increasing throughput. The technical development within the project is lead by the SME, TSE Systems GmbH, who will work with some of the leading mouse phenotyping centres in Europe at MRC, UK, CNR, Italy and GSF, Germany. The objectives are: 1) High-throughput Phenotyping: a) Development of a new high-throughput automated phenotyping platform PSS009 using home cage monitoring. 2) Development of new EMPReSS SOPs using PSS009 and validation of this approach with selected mouse models at different sites / European mouse clinics (cross-checking / cross-validation). 3) Optimization of the high-throughput technology systems by advanced interfacing and extended software capabilities. 4) Promotion of the new high-throughput systems and novel established SOPs to other phenotyping centres.'