TANDEM

Developing Tandem Reaction Sequences for the Rapid Synthesis of Selected Bioactive Natural Products Followed by Parallel synthesis of analogue libraries and Biological Evaluation

Coordinatore	PANEPISTIMIO KRITIS    more  Organization address address: UNIVERSITY CAMPUS GALLOS city: RETHIMNO postcode: 74100 contact info Titolo: Ms. Nome: Eva Cognome: Michelidaki Email: send email Telefono: -395935 Fax: -395910
Nazionalità Coordinatore	Greece [EL]
Totale costo	45˙000 €
EC contributo	45˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-2-ERG
Funding Scheme	MC-ERG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-04-30   -   2011-04-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	PANEPISTIMIO KRITIS  Organization address address: UNIVERSITY CAMPUS GALLOS city: RETHIMNO postcode: 74100 contact info Titolo: Ms. Nome: Eva Cognome: Michelidaki Email: send email Telefono: -395935 Fax: -395910	EL (RETHIMNO)	coordinator	0.00

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 Obiettivo del progetto (Objective)

A proposal for the concise synthesis of a family of cytotoxic natural products obtained from Polythia Crassa is contained herein. The short and highly effcient synthesis accesses all the structurally diverse family members from two simple common precursors. The synthesis makes use of novel tandem reaction sequences to access these molecules. The molecules and their syntheses are amenable to the inclusion of structural modifications and libraries of structurally diverse analogues will therefore be made using parallel synthesis techniques. Natural and synthetic compounds will then be tested against a panel of human tumour cell lines allowing iterative redesign of analogues to be undertaken in order to hone the activity and pharmacokinetic profile of promising lead compounds.