UB

Construction of Well- defined Ubiquitin Conjugates

Coordinatore	STICHTING HET NEDERLANDS KANKER INSTITUUT    more  Organization address address: PLESMANLAAN 121 city: AMSTERDAM postcode: 1066 CX contact info Titolo: Dr. Nome: Henri Cognome: Van Luenen Email: send email Telefono: +31 20 512 2097 Fax: +31 20 669 1383
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	45˙000 €
EC contributo	45˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-ERG-2008
Funding Scheme	MC-ERG
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-10-15   -   2011-10-14

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	STICHTING HET NEDERLANDS KANKER INSTITUUT  Organization address address: PLESMANLAAN 121 city: AMSTERDAM postcode: 1066 CX contact info Titolo: Dr. Nome: Henri Cognome: Van Luenen Email: send email Telefono: +31 20 512 2097 Fax: +31 20 669 1383	NL (AMSTERDAM)	coordinator	45˙000.00

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 Obiettivo del progetto (Objective)

'Ubiquitination and deubiquitination of proteins has emerged as an important biological regulatory process. For any investigational and therapeutical purposes, well-defined ubiquitin(-like) conjugates are of prime importance and to date, these have mainly been constructed by enzyme based strategies. However, besides the general potential problems of enzymatic transformations (e.g. yield, isolation, expression), the promiscuous nature of ubiquitination severely limits their general applicability. Despite this and the growing evidence that structural organization of ubiquitin chains is more complicated and important than anticipated, the development of synthetic strategies towards well-defined Ub(ls) has received little attention. This proposal will present synthetic strategies which I believe hold great potential as general approaches towards well-defined ubiquitin conjugates. Chemical approaches and resulting reagents are not only desired for their analytical value but will also assist future developments of targeted therapeutics.'