SYSTEQ

"The development, validation and implementation of human systemic Toxic Equivalencies (TEQs) as biomarkers for dioxin-like compounds"

Coordinatore	UNIVERSITEIT UTRECHT    more  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Ms. Nome: Monique Cognome: Van Der Hoek Email: send email Telefono: 31302533566 Fax: 31302535077
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	3˙532˙263 €
EC contributo	2˙703˙596 €
Programma	FP7-ENVIRONMENT Specific Programme "Cooperation": Environment (including Climate Change)
Code Call	FP7-ENV-2008-1
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-02-01   -   2013-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT UTRECHT  Organization address address: Heidelberglaan 8 city: UTRECHT postcode: 3584 CS contact info Titolo: Ms. Nome: Monique Cognome: Van Der Hoek Email: send email Telefono: 31302533566 Fax: 31302535077	NL (UTRECHT)	coordinator	864˙141.00
2	UMEA UNIVERSITET  Organization address address: UNIVERSITETOMRADET city: UMEA postcode: 901 87 contact info Titolo: Dr. Nome: Patrik Cognome: Anderson Email: send email Telefono: 46907865266 Fax: +46 90 786 76 55	SE (UMEA)	participant	499˙800.00
3	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Riitta Cognome: Ljungstrom Email: send email Telefono: +46 8 5248 7321 Fax: +46 8 33 93 80	SE (STOCKHOLM)	participant	498˙600.00
4	TECHNISCHE UNIVERSITAET KAISERSLAUTERN  Organization address address: GOTTLIEB-DAIMLER-STRASSE Geb. 47 city: KAISERSLAUTERN postcode: 67663 contact info Titolo: Mr. Nome: Berthold Cognome: Klein Email: send email Telefono: 496312000000 Fax: 496312000000	DE (KAISERSLAUTERN)	participant	474˙295.70
5	VYZKUMNY USTAV VETERINARNIHO LEKARSTVI  Organization address address: Hudcova 70 city: BRNO postcode: 62132 contact info Titolo: Ms. Nome: Marketa Cognome: Kabourkova Email: send email Telefono: +420 533 332 503 Fax: +420 533 332 503	CZ (BRNO)	participant	318˙759.56
6	SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE  Organization address address: LIMBOVA 12 city: BRATISLAVA postcode: 83303 contact info Titolo: Mr. Nome: Milan Cognome: Cagan Email: send email Telefono: 421259000000 Fax: 421259000000	SK (BRATISLAVA)	participant	48˙000.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Chlorinated dioxins and biphenyls (PCBs) commonly occur in the human food chain and can still be detected at levels that might cause long term health effects. Exposure to dioxin-like compounds involves a complex mixture with a common mechanism of action involving endocrine, developmental, carcinogenic, immuno and neurological effects. Risk assessment is done with an additive model for mixture toxicity. Based on this the Toxic Equivalency (TEQ) concept was developed as a biomarker for exposure and risk. TEQs are the sum of congener-specific toxic equivalency factors (TEFs) multiplied by the concentration in a matrix, e.g. blood. TEF values are a composite quantitative value from a range of biomarkers that are congener and endpoint specific. Present human TEQs have been derived from oral administration experiments providing ‘intake’ TEFs. Regulatory authorities frequently use ‘intake’ TEQs for blood and tissues considering it a biomarker for exposure or effect. Experimental evidence shows that using ‘uptake’ TEQs as ‘systemic’ biomarkers may lead to misinterpretation of risks. Therefore, development and validation of ‘systemic’ TEFs and TEQs as biomarkers is necessary. Major objectives of SYSTEQ are: i) establish ‘systemic’ TEFs and TEQs, ii) identify novel quantifiable biomarkers with newest molecular methods, e.g. genetic fingerprinting profiles, iii) extra focus on effects in peripheral lymphocytes as biomarkers, iv) identify differences between humans and experimental species. The ‘systemic’ TEFs and TEQs from SYSTEQ will be used in conjunction with results of the completed EU PCBRISK project, in which two populations from Slovakia with very different exposure were studied. Individual blood levels and different biomarkers are already available. Results of SYSTEQ are also going to be used to establish international consensus values of ‘systemic’ TEFs at WHO level, facilitating the global use of ‘systemic’ TEQs as biomarkers of effect and exposure.'

Introduzione (Teaser)

Assessing the risk associated with potentially toxic compounds is important to limit their impact on human health. A recent project has updated standard measures of toxicity for a common group of toxins.