OBELIX

OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life

Coordinatore	STICHTING VU-VUMC    more  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Dr. Nome: Yvonne Cognome: Kops Email: send email Telefono: +31 20 5987304 Fax: +31 20 5989950
Nazionalità Coordinatore	Netherlands [NL]
Sito del progetto	http://www.theobelixproject.org
Totale costo	3˙918˙991 €
EC contributo	2˙999˙692 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2008-2B
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-05-01   -   2013-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	STICHTING VU-VUMC  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Dr. Nome: Yvonne Cognome: Kops Email: send email Telefono: +31 20 5987304 Fax: +31 20 5989950	NL (AMSTERDAM)	coordinator	980˙064.00
2	RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN  Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA contact info Titolo: Mr. Nome: Remco Cognome: Van Den Dikkenberg Email: send email Telefono: +31 30 274 2681 Fax: +31 30 274 4446	NL (BILTHOVEN)	participant	808˙460.00
3	VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.  Organization address address: Boeretang 200 city: MOL postcode: 2400 contact info Titolo: Prof. Nome: Greet Cognome: Schoeters Email: send email Telefono: 3214335200	BE (MOL)	participant	616˙895.00
4	NASJONALT FOLKEHELSEINSTITUTT  Organization address address: Lovisenberggata 8 city: OSLO postcode: 403 contact info Titolo: Mr. Nome: Frederik Cognome: Froen Email: send email Telefono: +47 21 07 7000 Fax: +47 21 07 78252	NO (OSLO)	participant	264˙138.00
5	SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE  Organization address address: LIMBOVA 12 city: BRATISLAVA postcode: 83303 contact info Titolo: Ms. Nome: Milan Cognome: Cagan Email: send email Telefono: +421 2 5930650 Fax: +421 2 5930652	SK (BRATISLAVA)	participant	200˙000.00
6	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE  Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Mr. Nome: Jean-Jacques Cognome: Petitdidier Email: send email Telefono: +33 142759276 Fax: +33 144087276	FR (PARIS CEDEX 07)	participant	101˙047.00
7	STICHTING ECOBABY  Organization address address: Hollandstraat 6 city: Loenersloot postcode: 3634 AT contact info Titolo: Dr. Nome: Aart Cognome: Blom Email: send email Telefono: +31 20 6797938 Fax: +31 294 291373	NL (Loenersloot)	participant	29˙088.00
8	VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG  Organization address address: De Boelelaan 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Ms. Nome: Margot Cognome: Rijerse Email: send email Telefono: +31 20 59 89 561 Fax: +31 20 59 89 553	NL (AMSTERDAM)	participant	0.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'The incidence of childhood obesity has reached ‘epidemic’ proportions globally and there is an urgent need to increase our understanding of the impact of food contaminants on obesity development. The OBELIX project will examine the hypothesis that prenatal exposure to endocrine disrupting compounds (EDCs) in food plays a role in the development of obesity later in life. OBELIX proposes a multidisciplinary approach that combines epidemiology, neonatology, endocrinology, toxicology, analytical chemistry and risk assessment to address the objectives of the project: 1) To assess prenatal exposure in humans to major classes of EDCs in food identified as potential inducers of obesity (i.e. dioxins, non- and dioxin-like polychlorinated biphenyls, brominated flame retardants, phthalates and perfluorinated alkyl acids) using mother-child cohorts from four European regions with different food contaminant exposure patterns; 2) To relate early life exposure to EDCs with clinical markers, novel biomarkers and health effect data related to obesity; 3) To perform hazard characterization of in utero exposure to EDCs for the development of obesity later in life, using dose-response analysis in a rodent model; 4) To determine mechanisms of action of obesogenic EDCs on developmental programming with genomics and epigenetic analysis in in vivo and in vitro models; and, 5) to perform risk assessment of prenatal exposure to obesogenic EDCs in food, by integrating maternal exposure through food, contaminant exposure and health effect data in children, and hazard data. The outcomes of OBELIX are of particular relevance to the Work Programme, as the proposed project will generate new knowledge about prenatal exposure to major classes of EDCs in food that are potential inducers of obesity and related metabolic diseases later in life. It will also contribute new knowledge about effects of early exposure to EDCs on human health, including causality in animal models and possible mechanisms.'

Introduzione (Teaser)

A growing body of evidence points to the possibility that the origins of childhood obesity may be present before birth. A European research project explored the prenatal factors behind this relatively new phenomenon.