#	Pagina
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PRIORITY

Protecting the food chain from prions: shaping European priorities through basic and applied research

Coordinatore	UNIVERSIDADE DE SANTIAGO DE COMPOSTELA Organization address address: "PAZO DE SAN XEROME, PRAZA DO OBRADOIRO S/N" city: SANTIAGO DE COMPOSTELA postcode: 15782 contact info Titolo: Mr. Nome: Martin Cognome: Cacheiro Martinez Email: send email Telefono: +34 881 816233 Fax: +34 881 816263
Nazionalità Coordinatore	Spain [ES]
Sito del progetto	http://www.prion-priority.eu/web/
Totale costo	7˙904˙904 €
EC contributo	5˙999˙499 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2007-2A
Funding Scheme	CP-IP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-10-01 - 2014-09-30

Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSIDADE DE SANTIAGO DE COMPOSTELA Organization address address: "PAZO DE SAN XEROME, PRAZA DO OBRADOIRO S/N" city: SANTIAGO DE COMPOSTELA postcode: 15782 contact info Titolo: Mr. Nome: Martin Cognome: Cacheiro Martinez Email: send email Telefono: +34 881 816233 Fax: +34 881 816263	ES (SANTIAGO DE COMPOSTELA)	coordinator	564˙126.00
2	UNIVERSITAET ZUERICH Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Prof. Nome: Adriano Cognome: Aguzzi Email: send email Telefono: +41 44 255 2869 Fax: +41 44 255 44 02	CH (ZURICH)	participant	438˙124.00
3	UNIVERSITAT DE BARCELONA Organization address address: GRAN VIA DE LES CORTS CATALANES 585 city: BARCELONA postcode: 8007 contact info Titolo: Mr. Nome: Xavier Cognome: Gutierrez Email: send email Telefono: +34 93 4035385 Fax: +34 93 4489434	ES (BARCELONA)	participant	378˙124.00
4	FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT Organization address city: GREIFSWALD-INSEL RIEMS postcode: 17493 contact info Titolo: Ms. Nome: Lorena Cognome: Retana Calderon Email: send email Telefono: +49 383517 1351 Fax: +49 383517 1219	DE (GREIFSWALD-INSEL RIEMS)	participant	361˙248.00
5	INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE Organization address address: Rue De L'Universite 147 city: PARIS CEDEX 07 postcode: 75338 contact info Titolo: Ms. Nome: Michèle Cognome: Serthelon Email: send email Telefono: +33 5 61 19 38 70 Fax: +33 5 61 19 39 75	FR (PARIS CEDEX 07)	participant	348˙498.00
6	HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Organization address address: UNIVERSITAETSSTRASSE 1 city: DUSSELDORF postcode: 40225 contact info Titolo: Mr. Nome: Peter Cognome: Bons Email: send email Telefono: +49 211 8117127	DE (DUSSELDORF)	participant	345˙874.00
7	INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 contact info Titolo: Dr. Nome: Nadia Cognome: Khelef Email: send email Telefono: +33 1 40613378 Fax: +33 1 40613940	FR (PARIS CEDEX 15)	participant	345˙874.00
8	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Eva Cognome: Tegelberg Email: send email Telefono: 46852487855 Fax: 468333834	SE (STOCKHOLM)	participant	345˙874.00
9	THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 6509024 Fax: +44 131 6509023	UK (EDINBURGH)	participant	330˙874.00
10	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 contact info Titolo: Ms. Nome: Christiane Cognome: Hennecke Email: send email Telefono: +49 551 398770 Fax: +49 551 3922593	DE (GOETTINGEN)	participant	330˙874.00
11	PRIONICS AG Organization address address: WAGISTRASSE 27 A city: SCHLIEREN postcode: 8952 contact info Titolo: Dr. Nome: Alex Cognome: Raeber Email: send email Telefono: +41 44 2002000 Fax: +41 44 2002009	CH (SCHLIEREN)	participant	308˙374.00
12	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI Organization address address: VIA BONOMEA 265 city: TRIESTE postcode: 34136 contact info Titolo: Ms. Nome: Giuliana Cognome: Zotta Email: send email Telefono: +39 040 3787201 Fax: +39 040 3787249	IT (TRIESTE)	participant	308˙374.00
13	INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA Organization address address: Carretera de la Coruna Km7.5 city: MADRID postcode: 28040 contact info Titolo: Ms. Nome: María Cognome: Alarcón Alarcón Email: send email Telefono: +34 91 3473966 Fax: +34 91 3474084	ES (MADRID)	participant	300˙892.00
14	STICHTING HET NEDERLANDS KANKER INSTITUUT Organization address address: PLESMANLAAN 121 city: AMSTERDAM postcode: 1066 CX contact info Titolo: Dr. Nome: Henri G. A. M. Cognome: Van Luenen Email: send email Telefono: +31 20 5122097 Fax: +31 20 6691383	NL (AMSTERDAM)	participant	295˙248.00
15	THE HEBREW UNIVERSITY OF JERUSALEM. Organization address address: GIVAT RAM CAMPUS city: JERUSALEM postcode: 91904 contact info Titolo: Ms. Nome: Jane Cognome: Turner Email: send email Telefono: +972 2 6586676 Fax: +972 2 6513205	IL (JERUSALEM)	participant	254˙748.00
16	SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE Organization address address: LIMBOVA 12 city: BRATISLAVA postcode: 83303 contact info Titolo: Mr. Nome: Milan Cognome: Cagan Email: send email Telefono: +421 2 59370 651 Fax: +421 2 59370 652	SK (BRATISLAVA)	participant	239˙750.00
17	SMP GMBH - PRUEFEN VALIDIEREN FORSCHEN Organization address address: Hechinger strasse 262 city: TUBINGEN postcode: 72072 contact info Titolo: Mr. Nome: Klaus Cognome: Roth Email: send email Telefono: +49 7071 8578930 Fax: +49 7071 857893200	DE (TUBINGEN)	participant	153˙874.00
18	UNIVERSITAET HOHENHEIM Organization address address: Schloss Hohenheim 1 city: STUTTGART postcode: 70599 contact info Titolo: Prof. Nome: Hans-Peter Cognome: Liebig Email: send email Telefono: +49 711 459 0 Fax: +49 711 459 24050	DE (STUTTGART)	participant	153˙874.00
19	VETERINAERINSTITUTTET - NORWEGIAN VETERINARY INSTITUTE Organization address address: ULLEVALSVEIEN 68 city: OSLO postcode: 454 contact info Titolo: Mr. Nome: Frode åsmund Cognome: Granås Email: send email Telefono: +47 2321 6150 Fax: +47 2321 6001	NO (OSLO)	participant	77˙375.00
20	UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD contact info Titolo: Mr. Nome: Ralf Cognome: Henskens Email: send email Telefono: +31 43 3881967 Fax: +31 43 3884163	NL (MAASTRICHT)	participant	74˙000.00
21	THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS Organization address address: Area 1A, Nobel House, Smith Square 17 city: LONDON postcode: SW1P 3JR contact info Titolo: Ms. Nome: Lucinda Cognome: Cranham Email: send email Telefono: +44 1932 359571 Fax: +44 1932 357230	UK (LONDON)	participant	43˙500.00

Mappa

Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

formulated tse biology infection structure spongiform ago prion years chain blood caused meal strains infectious atypical encephalopathy decontamination bse questions prpsc function prevent risk infectivity species proteins mad found human ban strategies cow transmission spread prions bovine meat humans food data disease brain us exposure vcjd molecular cjd bone

Obiettivo del progetto (Objective)

'Bovine Spongiform Encephalopathy (BSE) started, 20 years ago, a devastating health and food crisis throughout Europe. Classical BSE is now under control as a result of the meat and bone meal ban. However, tonsil analyses suggest that there may be an alarmingly high number of asymptomatic PrPSc positive cases. Transmission through blood transfusion is another important concern, as are recent “atypical cases” of BSE. Only a profound understanding of the molecular biology of prions will enable us to control them. Thus, to understand why BSE-contaminated food causes vCJD, we need to understand how prions get into food, what happens with them in the gut, how they reach the brain, and how they initiate the chain reaction rapidly leading to death. We have formulated 7 key questions: 1) How can we avoid a new BSE outbreak, or other possible future prion infection of livestock? 2) Why did decontamination of meat and bone meal fail; is there an effective way to decontaminate feedstuffs, soil etc? 3) What is the risk of humans being infected with each of the different prion strains known thus far? 4) Which are the best strategies to implement feasible prion eradication programs? 5) How can we develop a pre-clinical prion blood test? 6) How can we identify human cases with potential secondary transmission? And 7) What is the origin of atypical human CJD cases? We will search for decisive data on the structure of PrPSc, the molecular basis of strains and species barriers, the mechanism of prion conversion, the cell biology of PrPSc, the function of PrPC, and the mechanisms of PrP-associated pathology. This information will be translated into a better estimation of current exposure risk to humans from TSE, evaluation of current intervention strategies, and development of improved decontamination techniques and prion tests. With all this, we will be able to respond to the questions formulated and thus advise the EC on TSE policy for the protection of European consumers..'

Introduzione (Teaser)

Proteins in general are good for us; but mis-folded proteins known as prions that caused the infectious mad cow disease are a different story. An EU-supported project is studying prions in order to prevent a recurrence of mad-cow disease or variant Creutzfeldt-Jakob disease (vCJD).

Descrizione progetto (Article)

Bovine Spongiform Encephalopathy (BSE), also called mad cow disease, decimated European cow populations over 20 years ago and caused major food scares across Europe. It even leapt across the species barrier to infect some humans with vCJD, killing around 200 people.

BSE and CJD are both caused by prions (infectious agents composed of misfolded proteins). Extensive research is required to prevent or deal with emergence of diseases due to prion infection.

Funded under the Seventh Framework Programme (FP7), the PRIORITY project sought to protect Europe's food chain by improving our understanding of prions. The EU-backed project focused on four areas related to prions: structure and function, detection, transmission and their epidemiology.

To investigate the structure of different prions, PRIORITY used cryo-electron microscopy and tomography, as well as various biochemical approaches. The project also studied how prions spread within an organism (including the brain) and the infectivity dynamics of blood and milk. Researchers found that prions spread from exposure site to brain via accumulation in follicular dendritic cells (FDCs).

PRIORITY confirmed that the ban on meat and bone meal (MBM) was the most significant factor supporting the containment of BSE, and recommended continuing the ban. TThe project also found that prion infectivity is quite persistent in wastewater.

Once complete, PRIORITY will help the EU deliver one of its major food safety priorities: safeguarding the food chain from fork to farm. Research data could identify factors that help prions flourish and spread across different species and the means to disrupt it.