BIOCHEMLIG
Bio-Orthogonal Chemo-Specific Ligation
| Coordinatore | UNIVERSITE DE STRASBOURG
Organization address
address: rue Blaise Pascal 4 contact info |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 3˙322˙086 € |
| EC contributo | 3˙322˙086 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-ITN-2008 |
| Funding Scheme | MC-ITN |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-10-01 - 2013-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITE DE STRASBOURG
Organization address
address: rue Blaise Pascal 4 contact info |
FR (Strasbourg) | coordinator | 667˙996.70 |
| 2 |
ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA
Organization address
address: Via Zamboni 33 contact info |
IT (BOLOGNA) | participant | 579˙589.06 |
| 3 |
UNIVERSITAET BASEL
Organization address
address: Petersplatz 1 contact info |
CH (BASEL) | participant | 434˙707.00 |
| 4 |
UNIVERSITAET BERN
Organization address
address: Hochschulstrasse 4 contact info |
CH (BERN) | participant | 434˙706.97 |
| 5 |
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Organization address
address: RUE LEBLANC 25 contact info |
FR (PARIS 15) | participant | 402˙474.75 |
| 6 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
UK (OXFORD) | participant | 396˙892.28 |
| 7 |
KEMIJSKI INSTITUT
Organization address
address: HAJDRIHOVA 19 contact info |
SI (LJUBLJANA) | participant | 227˙216.19 |
| 8 |
caprotec bioanalytics GmbH
Organization address
address: Volmerstrasse 5 contact info |
DE (Berlin) | participant | 178˙504.00 |
Mappa
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Obiettivo del progetto (Objective)
'The Post-genomic era calls for a deep understanding of protein structure and function. The elucidation of protein structures, localization, post-translation modifications, and protein-macromolecule interactions are important to establish their role in the biology of the cell. To establish their role and investigate the protein functions requires the integration of various complementary disciplines. Among all disciplines, chemistry is central in establishing new effective ways to manipulate a biological entity to understand cellular processes with molecular precision. For studying, analyzing and manipulating a macromolecule, the site-specific incorporation of reporter molecules, by virtue of ligation reactions, is a key factor. The BioChemLig research project presented herein describes novel approaches for the discovery of new bio-compatible and chemo-specific ligation reactions. The aim of this project is to develop new ligation processes with high efficiency, large scope of application, high chemoselectivity and high rates. Through a well established network, with demonstrated success (IBAAC Project: FP6-505020), we propose to focus our efforts in a highly combined and integrated training research action conducting research and using: unusual organic chemical functionalities for ligation, environmentally benign “on water” ligation reactions, specific 18F radiolabelled reagents, dendrimers conjugation methodologies, high-throughput screening for bond forming reactions, bio-chemo informatics platform for theoretical investigations, artificial metalo-enzymes for template-directed ligation, templated ligation reactions and HTS. This high quality integrated research should ultimately allow scientists to dissect cellular processes with molecular precision, speed up preparation of library of bioconjugates and deliver innovatives approaches to chemical biology.'
Introduzione (Teaser)
Bioorthogonal chemistry uses covalent chemistry to track biomolecules in their native environment. An EU project prioritised development of new, environmentally friendly and versatile chemical ligation methods.