MUT2DIS

New methods to evaluate the impact of single point protein mutation on human health

Coordinatore	UNIVERSITAT DE LES ILLES BALEARS    more  Organization address address: CARRETERA DE VALLDEMOSSA KM 7.5 city: PALMA DE MALLORCA postcode: 7122 contact info Titolo: Dr. Nome: Jairo Cognome: Rocha Email: send email Telefono: -173906 Fax: +34-971-173 003
Nazionalità Coordinatore	Spain [ES]
Totale costo	217˙113 €
EC contributo	217˙113 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IOF-2008
Funding Scheme	MC-IOF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-09-01   -   2012-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAT DE LES ILLES BALEARS  Organization address address: CARRETERA DE VALLDEMOSSA KM 7.5 city: PALMA DE MALLORCA postcode: 7122 contact info Titolo: Dr. Nome: Jairo Cognome: Rocha Email: send email Telefono: -173906 Fax: +34-971-173 003	ES (PALMA DE MALLORCA)	coordinator	217˙113.92

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 Obiettivo del progetto (Objective)

'The Single Nucleotide Polymorphisms (SNPs) are the main cause of the sequence variability in human. For this reason, the prediction of the impact of SNPs is one of the most challenging problems in computational biology and bioinformatics. The increasing growth of the genome-scale studies is providing a large amounts of SNP data, allowing the application of rigorous statistical approaches for predicting whether a given single point mutation has an effect on human health. In spite of the scientific effort, the identification of disease-associated human SNPs remains a difficult task and a satisfactory solution of general applicability is yet unavailable. This proposal is focused on the study of those SNPs, called missense SNPs (mSNPs), that are responsible of single protein mutation, because the mSNPs can be related to the insurgence of pathologies decreasing the stability or the functional activity of the protein. The main aim of this project concerns the development of new machine learning based methods to predict the effect of a given single point protein mutation. A set of mSNPs corresponding to proteins with known with atomic resolution will be collected and studied evaluating the evolutionary information retrieved using the protein sequences and the structural information derived from the protein 3D structures. The description of the structural and evolutionary related features will allow the implementation of more accurate predictors able to discriminate between disease causing or neutral polymorphisms. In a second part of the project, the resulting predictors will be also used to elucidate the relationships between mSNPs and the resistance to a given drugs. This aspect will be vary important in order to evaluate which therapy could have better effect on a particular phenotype. All the results of this research as well as the implemented predictors will be made available online to scientific community.'