PEPTIDEBASEDHYDROGEL
Toward the development of peptide-based hydrogels for tissue regeneration applications with inherent antibacterial activity
| Coordinatore | INSTITUTO DE MEDICINA MOLECULAR
Organization address
address: AVENIDA PROF EGAS MONIZ contact info |
| Nazionalità Coordinatore | Portugal [PT] |
| Totale costo | 235˙102 € |
| EC contributo | 235˙102 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-IOF-2008 |
| Funding Scheme | MC-IOF |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-11-01 - 2012-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
INSTITUTO DE MEDICINA MOLECULAR
Organization address
address: AVENIDA PROF EGAS MONIZ contact info |
PT (LISBOA) | coordinator | 235˙102.89 |
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Obiettivo del progetto (Objective)
'Hydrogels are heavily hydrated materials finding use as delivery vehicles in autologous tissue engineering. In one approach, healthy cells are first isolated from the patient and expanded in the lab. The cells are then encapsulated in a hydrogel and the resulting gel/cell construct is injected into the wound site where healing is catalyzed by the implanted cells. Although early efforts show promise, implant-centered infections can be problematic since the microenvironment of many hydrogels are not only ideal for the intended mammalian cells but also for opportunistic bacteria. In this proposal, a multidisciplinary approach entailing structure-based peptide design, biophysical and materials properties analysis as well as mammalian and bacterial cell culturing will be used to formulate a peptide-based hydrogel that meets the stringent requirements for mammalian cell encapsulation and delivery, yet is also inherently antibacterial. This work will result in novel materials that will find immediate use in tissue engineering.'
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