PEPTIDEBASEDHYDROGEL

Toward the development of peptide-based hydrogels for tissue regeneration applications with inherent antibacterial activity

Coordinatore	INSTITUTO DE MEDICINA MOLECULAR    more  Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 contact info Titolo: Dr. Nome: Margarida Cognome: Pinto Gago Email: send email Telefono: 351218000000 Fax: 351218000000
Nazionalità Coordinatore	Portugal [PT]
Totale costo	235˙102 €
EC contributo	235˙102 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IOF-2008
Funding Scheme	MC-IOF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-11-01   -   2012-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUTO DE MEDICINA MOLECULAR  Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 contact info Titolo: Dr. Nome: Margarida Cognome: Pinto Gago Email: send email Telefono: 351218000000 Fax: 351218000000	PT (LISBOA)	coordinator	235˙102.89

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 Obiettivo del progetto (Objective)

'Hydrogels are heavily hydrated materials finding use as delivery vehicles in autologous tissue engineering. In one approach, healthy cells are first isolated from the patient and expanded in the lab. The cells are then encapsulated in a hydrogel and the resulting gel/cell construct is injected into the wound site where healing is catalyzed by the implanted cells. Although early efforts show promise, implant-centered infections can be problematic since the microenvironment of many hydrogels are not only ideal for the intended mammalian cells but also for opportunistic bacteria. In this proposal, a multidisciplinary approach entailing structure-based peptide design, biophysical and materials properties analysis as well as mammalian and bacterial cell culturing will be used to formulate a peptide-based hydrogel that meets the stringent requirements for mammalian cell encapsulation and delivery, yet is also inherently antibacterial. This work will result in novel materials that will find immediate use in tissue engineering.'