INFRAVEC
Research capacity for the implementation of genetic control of mosquitoes
| Coordinatore | IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 10˙782˙699 € |
| EC contributo | 8˙499˙618 € |
| Programma | FP7-INFRASTRUCTURES
Specific Programme "Capacities": Research infrastructures |
| Code Call | FP7-INFRASTRUCTURES-2008-1 |
| Funding Scheme | CP-CSA-Infra |
| Anno di inizio | 2009 |
| Periodo (anno-mese-giorno) | 2009-09-01 - 2014-02-28 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
UK (LONDON) | coordinator | 2˙488˙550.00 |
| 2 |
UNIVERSITA DEGLI STUDI DI PERUGIA
Organization address
address: PIAZZA DELL' UNIVERSITA 1 contact info |
IT (PERUGIA) | participant | 1˙072˙677.44 |
| 3 |
ISTITUTO SUPERIORE DI RICERCA E FORMAZIONE SUI MATERIALI SPECIALI PERTECNOLOGIE AVANZATE SCRL IN BREVE ISRIM S.CONS. A R.L.
Organization address
address: LOCALITA PENTIMA BASSA 21 contact info |
IT (Terni) | participant | 507˙788.30 |
| 4 |
CENTRO AGRICOLTURA E AMBIENTE GIORGIO NICOLI SRL
Organization address
address: VIA ARGINI NORD 3351 contact info |
IT (CREVALCORE) | participant | 451˙149.87 |
| 5 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange 3 contact info |
FR (PARIS) | participant | 360˙237.99 |
| 6 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | participant | 301˙769.60 |
| 7 |
UNIVERSITY OF KEELE
Organization address
address: KEELE UNIVERSITY FINANCE DPT contact info |
UK (KEELE) | participant | 287˙942.50 |
| 8 |
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Organization address
address: Meyerhofstrasse 1 contact info |
DE (HEIDELBERG) | participant | 223˙377.00 |
| 9 |
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Organization address
address: Piazzale Aldo Moro 5 contact info |
IT (ROMA) | participant | 184˙928.82 |
| 10 |
INSTITUTO DE HIGIENE E MEDICINA TROPICAL
Organization address
address: Rua da Junqueira 100 contact info |
PT (LISBOA) | participant | 179˙900.00 |
| 11 |
Oxitec Limited
Organization address
address: Miton park 71 contact info |
UK (Oxford) | participant | 178˙630.00 |
| 12 |
FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS
Organization address
address: N PLASTIRA STR 100 contact info |
EL (HERAKLION) | participant | 152˙656.00 |
| 13 |
LIVERPOOL SCHOOL OF TROPICAL MEDICINE
Organization address
address: Pembroke Place contact info |
UK (LIVERPOOL) | participant | 150˙760.00 |
| 14 |
ISTITUTO SUPERIORE DI SANITA
Organization address
address: Viale Regina Elena 299 contact info |
IT (ROMA) | participant | 142˙600.00 |
| 15 |
WAGENINGEN UNIVERSITY
Organization address
address: DROEVENDAALSESTEEG 4 contact info |
NL (WAGENINGEN) | participant | 138˙000.00 |
| 16 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
UK (OXFORD) | participant | 135˙970.00 |
| 17 |
Nome Ente NON disponibile
Organization address
address: Rue du Centre Pasteur 2007 contact info |
CM (Yaounde) | participant | 124˙450.00 |
| 18 |
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
Organization address
address: Boulevard de Dunkerque - CS 90009 44 contact info |
FR (MARSEILLE) | participant | 121˙370.00 |
| 19 |
International Centre of Insect Physiology and Ecology
Organization address
address: "Off Thika Road, Duduville Campus" contact info |
KE (Nairobi) | participant | 119˙995.00 |
| 20 |
MINISTERE DE LA SANTE
Organization address
city: 7003 Ouagadougou 03 contact info |
BF (7003 Ouagadougou 03) | participant | 117˙619.00 |
| 21 |
CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE ET TECHNOLOGIQUE*INSTITUT DE RECHERCHE EN SCIENCES DE LA SANTE
Organization address
address: B P 7047 contact info |
BF (OUAGADOUGOU) | participant | 110˙000.00 |
| 22 |
UNIVERSITA DEGLI STUDI DI PAVIA
Organization address
address: STRADA NUOVA 65 contact info |
IT (PAVIA) | participant | 108˙270.00 |
| 23 |
AGRICULTURAL UNIVERSITY OF ATHENS
Organization address
address: Iera Odos 75 contact info |
EL (ATHENS) | participant | 107˙642.40 |
| 24 |
INSTITUT PASTEUR DE DAKAR
Organization address
address: Avenue Pasteur 36 contact info |
SN (DAKAR) | participant | 100˙450.00 |
| 25 |
STICHTING KATHOLIEKE UNIVERSITEIT
Organization address
address: GEERT GROOTEPLEIN NOORD 9 contact info |
NL (NIJMEGEN) | participant | 98˙849.60 |
| 26 |
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.
Organization address
address: Corso Umberto I 40 contact info |
IT (NAPOLI) | participant | 95˙401.18 |
| 27 |
UNIVERSITY OF GLASGOW
Organization address
address: University Avenue contact info |
UK (GLASGOW) | participant | 95˙190.00 |
| 28 |
UNIVERSITAETSKLINIKUM HEIDELBERG
Organization address
address: IM NEUENHEIMER FELD 672 contact info |
DE (HEIDELBERG) | participant | 93˙999.60 |
| 29 |
UNIVERSITA DEGLI STUDI DI CAMERINO
Organization address
address: PIAZZA CAVOUR 19F contact info |
IT (CAMERINO) | participant | 86˙704.00 |
| 30 |
MED BIOTECH LABORATORIES
Organization address
address: "Lugwana Close, Myenga Tank Hill By-Pass" contact info |
UG (KAMPALA) | participant | 82˙740.00 |
| 31 |
STOCKHOLMS UNIVERSITET
Organization address
address: Universitetsvaegen 10 contact info |
SE (STOCKHOLM) | participant | 80˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
Mosquitoes transmit a variety of infectious diseases that cause a tremendous burden to public health. Due to climate changes and to the increase in international trade and tourism the threats posed by mosquitoes are increasingly affecting large parts of Europe, causing understandable concerns among the populations of many Member States. Control methods, mainly based on insecticide usage, are struggling to cope with the challenges posed by the biology and ecology of mosquito vectors. INFRAVEC aims at bridging the gap between the recent advances in transgenic technology and its implementation as a novel powerful approach for vector control. To this aim, a large European Infrastructure will be established, in which the coordination of efforts, expertise and facilities provided by the individual research groups and institutions will bolster and considerably expand the overall research capabilities of the research community. INFRAVEC will operate, through a number of Networking, Joint Research, Transnational and Service activities, towards the objective of considerably strengthening research capability in Europe by sharing knowledge, resources and technology. INFRAVEC will mainly focus on Anopheles gambiae, the major vector of malaria, and Aedes albopictus, a viral disease vector that is rapidly spreading through Europe. Four Infrastructure facilities will be integrated in the project: 1) the Genetically Modified mosquito laboratory of Imperial College London; 2) the Mosquito Mass-rearing facility at the Centro Agricoltura ed Ambiente (with the support of the International Atomic Energy Agency); 3) the Bioinformatics facility at EMBLEBI, UK; and 4) the Mosquito Confined Release facility at ISRIM. INFRAVEC will provide a formidable research capability to external users and facilitate the performance of five research projects aimed at utilizing basic knowledge of mosquito genetics and biology in an unprecedented effort to develop novel opportunities for mosquito control.
Descrizione progetto (Article)
With climate change and increasing international trade and tourism, the threat of mosquito-carried disease is spreading. Conventional control methods employing insecticide use are struggling to meet the challenge.
The ability to target specific essential mosquito genes, and to introduce genes from one species into another using transgenic technology will possibly allow to control vector spread at genetic level. The EU-funded project 'Research capacity for the implementation of genetic control of mosquitoes' (INFRAVEC) is integrating mosquito genetics expertise with unique mosquito rearing and confined release infrastructures and offers researchers across Europe access to these cutting-edge research facilities. The consortium consists of 31 academic and industrial laboratories.
The multi-center facility offers to create and make available a comprehensive mosquito line repository facility for both genetically modified (GM) and field-derived mosquitoes. In addition, researchers acquired a custom-made, high-throughput, fully automated sorting instrument that allows to discriminate between genetically divergent mosquito larvae.
The two mosquito vectors provided for under this research infrastructure are Anopheles gambiae, the major vector of malaria, and Aedes albopictus, a vector carrying viral diseases that continues to spread. Genetic research resources for Ae. Albopictus are currently quite limited, but are being expanded under this project.
During this reporting period, a large effort was devoted to generating the required genetic databases. Investigators also made important progress towards understanding and genetically manipulating vectorial capacity, reproduction and immunity as routes to minimise their spread.
Researchers are also comparing the population structure of Ae. albopictus in its native habitat with those populations that have recently colonised Europe in order to identify genetic changes that may be associated with the spread of the new populations. Controlled release of GM mosquitoes is the ultimate goal. To that end, a small, 'semi-field' experimental set-up is currently being developed, a so-called confined release facility, that allows e.g. including studying the viability, competitiveness and safety of genetically modified mosquitos.
Mosquito-borne diseases are on the rise and spreading across the globe due to a combination of global climate change and increased trade and tourism. INFRAVEC brings together experts in mosquito biology, genetics, epidemiology, genetic engineering and more, to boost research to confront the spread of disease-carrying mosquitos that pose a great threat to public health.