MASC

MASC: Materials that Impose Architecture within Stem Cell Populations

Coordinatore	THE UNIVERSITY OF NOTTINGHAM    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙290˙856 €
EC contributo	2˙290˙856 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2008-AdG
Funding Scheme	ERC-AG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2014-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF NOTTINGHAM  Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD contact info Titolo: Mr. Nome: Paul Cognome: Cartledge Email: send email Telefono: +44 115 951 5679 Fax: +44 115 951 3633	UK (NOTTINGHAM)	hostInstitution	2˙290˙856.80
2	THE UNIVERSITY OF NOTTINGHAM  Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD contact info Titolo: Prof. Nome: Kevin Morris Cognome: Shakesheff Email: send email Telefono: -9515175 Fax: -9515193	UK (NOTTINGHAM)	hostInstitution	2˙290˙856.80

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 Obiettivo del progetto (Objective)

This proposal aims to harness breakthroughs in polymer science, nanotechnology and materials processing to create new classes of materials that mimic the architecture of the human body. The materials will be exploited to tackle grand challenges in stem cell science and in the development of new biomaterials that promote regeneration. The human body uses materials to impose architecture on populations of cells within developing or regenerating tissues. Architectural components of these tissues include three-dimensional spatial and temporal patterns of growth factors, spatial arrangements of multiple cell types and modulation of local elasticity. Orchestration of these architectural features is essential in the precise control of stem cell differentiation and tissue morphogenesis in vivo. This ERC Grant will create new classes of biomaterials that bridge the gap between the exquisite control of architecture in the developing human body and the crude structure imposed on cell populations in vitro during cell culture and biomaterials-assisted tissue repair. The research programme is organised into 2 major strands: TOOLS and DEMONSTRATORS. Within TOOLS, new materials and techniques will be invented that represent a step-change in our ability to impose architecture on stem cell populations in vitro. Within DEMONSTRATORS, 3 grand challenges in healthcare and stem cell science will be addressed through demonstrations that synthetic materials can be designed to match the architecture of our developing bodies. This interdisciplinary project will be undertaken by a team of interdisciplinary scientists within the Wolfson Centre for Stem Cells Tissue Engineering and Modelling (STEM). To undertake this research project help from collaborators across Europe is required. Existing and new collaborations will ensure that the most advanced materials science and stem cell biology is exploited to create world leading tools that radically change regenerative medicine.