DC-MTB INTERACTIONS

Visualization of Dendritic cell IL-12 production and engagement with antigen-specific T cells during Mycobacterium tuberculosis infection in vivo

Coordinatore	KAROLINSKA INSTITUTET    more  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Prof. Nome: Markus Cognome: Maeurer Email: send email Telefono: +46 8 4572315 Fax: +46 8 337460
Nazionalità Coordinatore	Sweden [SE]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-RG
Funding Scheme	MC-IRG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2013-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Prof. Nome: Markus Cognome: Maeurer Email: send email Telefono: +46 8 4572315 Fax: +46 8 337460	SE (STOCKHOLM)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Mycobacterium tuberculosis (Mtb) is a major pathogen that continues to trouble mankind and puzzle immunologists. There is today a growing need for a better understanding of Mtb infection. Dendritic cells (DC) are unique in that they both prime T cells and through IL-12 production direct their differentiation into anti-mycobacterial effector cells. So studying DC and IL-12 during infection has direct implications for improving our fundamental grasp of immunity to this pathogen. DC-T cell contacts occur in the lymph node (LN). However, if and where DC produce IL-12 in vivo remains unknown. In fact, most of the data on DC responses to Mtb comes from in vitro studies that fail to consider the microenvironment of the LN and its constraints on cell-cell and cell-pathogen interactions. The questions herein address the spatiotemporal regulation of mycobacterial antigen acquisition and IL-12 production by DC and whether they give rise to antigen-specific interactions with T cells that dictate effector function generation. These questions remain at large due to methodological impediments. Visualization techniques provide a valuable insight into the complex in situ interplay between DC, Mtb and T cells that governs the host-pathogen standoff. Improvements in imaging now permit the undertaking of these studies in full dynamic view. Visualizing these vital interactions offer new perspectives into understanding and thus manipulating DC for immunotherapy and vaccination benefits.'

Introduzione (Teaser)

Understanding the immune mechanisms that drive antigen presentation is central to vaccine development. A European study looked closely into the microenvironment and immune responses following tuberculosis vaccination.