NEUROHABIT

Neural mechanisms of action learning and action selection: from intent to habit

Coordinatore	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Portugal [PT]
Totale costo	1˙526˙304 €
EC contributo	1˙526˙304 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-StG
Funding Scheme	ERC-SG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-11-01   -   2014-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACAO CALOUSTE GULBENKIAN  Organization address address: AVENIDA DE BERNA 45A city: LISBOA postcode: 1000 contact info Titolo: Mr. Nome: José Mário Cognome: Leite Email: send email Telefono: 351214000000 Fax: 351214000000	PT (LISBOA)	beneficiary	769˙354.06
2	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD  Organization address address: AVENIDA BRASILIA city: LISBOA postcode: 1400 038 contact info Titolo: Dr. Nome: Rui Manuel Marques Fernandes Da Cognome: Costa Email: send email Telefono: 351210000000 Fax: 351210000000	PT (LISBOA)	hostInstitution	756˙949.94
3	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD  Organization address address: AVENIDA BRASILIA city: LISBOA postcode: 1400 038 contact info Titolo: Dr. Nome: Tania Cognome: Vinagre Email: send email Telefono: 351210000000 Fax: 351210000000	PT (LISBOA)	hostInstitution	756˙949.94

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 Obiettivo del progetto (Objective)

'In every day life, we constantly have to select the appropriate actions to obtain specific outcomes. Actions can be selected based on their consequences, for example when we press an elevator button to get to the particular floor where we live. This goal-directed behaviour is crucial to face the ever-changing environment but demands an effortful control and monitoring of the response; one way to balance the need for flexibility and efficiency is through automatization of recurring decision processes as a habit. Habitual responses no longer need the evaluation of their consequences, and can be elicited by particular situations or stimuli, for example when we press the button for our home floor in a building that we are visiting for the first time. There is growing evidence that the neural circuits underlying intentional or goal-directed actions are different from those underlying habits; associative corticostriatal circuits have been implicated in goal-directed actions, and sensorimotor circuits in habit formation. Dopamine (DA) has been implicated in both voluntary actions and habits. However, DA neurons from the VTA and the SNc project to different cortical and striatal regions, and the specific role of VTA and SNc DA in goal-directed actions and habits has not been clarified. We propose to: 1) use cell-type and region specific genetic manipulations to test if phasic firing in VTA or SNc DA neurons is necessary for goal-directed actions or habits, respectively, 2) generate cell-type specific channelrodhopsin transgenic mice to test if phasic DA neuron firing in these areas is sufficient to produce goal-directed actions or habits, and 3) selectively manipulate striatal neurons modulated by VTA or SNc phasic DA to test if they are necessary for goal-directed actions or habits. The dissection of the molecular and circuit mechanisms underlying goal-directed and habitual responses will be critical to understand decision-making, and the origins of compulsive behaviour.'