BIOSENSORIMAGING

Hyperpolarized Biosensors in Molecular Imaging

Coordinatore	FORSCHUNGSVERBUND BERLIN E.V.    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙848˙600 €
EC contributo	1˙848˙600 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-StG
Funding Scheme	ERC-SG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-12-01   -   2014-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FORSCHUNGSVERBUND BERLIN E.V.  Organization address address: Rudower Chaussee 17 city: BERLIN postcode: 12489 contact info Titolo: Dr. Nome: Anne Cognome: Höner Email: send email Telefono: +49 30 94793286 Fax: +49 30 94793109	DE (BERLIN)	hostInstitution	1˙848˙600.00
2	FORSCHUNGSVERBUND BERLIN E.V.  Organization address address: Rudower Chaussee 17 city: BERLIN postcode: 12489 contact info Titolo: Dr. Nome: Leif Cognome: Schröder Email: send email Telefono: -94793102 Fax: -94793170	DE (BERLIN)	hostInstitution	1˙848˙600.00

Mappa

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 Obiettivo del progetto (Objective)

'Xenon biosensors have an outstanding potential to increase the significance of magnetic resonance imaging (MRI) in molecular imaging and to combine the advantages of MRI with the high sensitivity of hyperpolarized Xe-129 and the specificity of a functionalized contrast agent. Based on new detection schemes (Hyper-CEST method) in Xe MRI, this novel concept in molecular diagnostics will be made available for biomedical applications. The advancement focuses on high-sensitivity in vitro diagnostics for localization of tumour cells in cell cultures and first demonstrations on animal models based on a transferrin-functionalized biosensor. Such a sensor will enable detection of subcutaneous tumours at high sensitivity without any background signal. More detailed work on the different available Hyper-CEST contrast parameters focuses on an absolute quantification of new molecular markers that will improve non-invasive tumour diagnostics significantly. NMR detection of functionalized Xe biosensors have the potential to close the sensitivity gap between modalities of nuclear medicine like PET/SPECT and MRI without using ionizing radiation or making compromises in penetration depth like in optical methods.'