METAPRO

The development of tools and effective strategies for the optimisation of useful secondary METAbolite PROduction in planta

Coordinatore	ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE    more  Organization address address: EGHAM HILL UNIVERSITY OF LONDON city: EGHAM postcode: TW20 0EX contact info Titolo: Dr. Nome: Paul Cognome: Fraser Email: send email Telefono: 0044(0)1784443894 Fax: 0044(0)1784414124
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	4˙137˙742 €
EC contributo	2˙981˙469 €
Programma	FP7-KBBE Specific Programme "Cooperation": Food, Agriculture and Biotechnology
Code Call	FP7-KBBE-2009-3
Funding Scheme	CP-FP
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-12-01   -   2013-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE  Organization address address: EGHAM HILL UNIVERSITY OF LONDON city: EGHAM postcode: TW20 0EX contact info Titolo: Dr. Nome: Paul Cognome: Fraser Email: send email Telefono: 0044(0)1784443894 Fax: 0044(0)1784414124	UK (EGHAM)	coordinator	531˙935.00
2	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Beatrice Cognome: Riedel Email: send email Telefono: 493316000000 Fax: 493316000000	DE (MUENCHEN)	participant	484˙000.00
3	ALBERT-LUDWIGS-UNIVERSITAET FREIBURG  Organization address address: FAHNENBERGPLATZ city: FREIBURG postcode: 79085 contact info Titolo: Prof. Nome: Peter Cognome: Beyer Email: send email Telefono: 497612000000 Fax: 497612000000	DE (FREIBURG)	participant	394˙650.00
4	THE SCOTTISH CROP RESEARCH INSTITUTE  Organization address address: "ERROL ROAD, INVERGOWRIE" city: DUNDEE postcode: DD2 5DA contact info Titolo: Dr. Nome: Mark Cognome: Taylor Email: send email Telefono: 0044(0)1382 562731 Fax: 0044(0)1382 562426	UK (DUNDEE)	participant	373˙604.00
5	AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE,L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE  Organization address address: Lungotevere Grande Ammiraglio Thaon di Revel 76 city: ROMA postcode: 196 contact info Titolo: Prof. Nome: Giovanni Cognome: Giuliano Email: send email Telefono: 390630000000 Fax: 390630000000	IT (ROMA)	participant	332˙000.00
6	THE HEBREW UNIVERSITY OF JERUSALEM.  Organization address address: GIVAT RAM CAMPUS city: JERUSALEM postcode: 91904 contact info Titolo: Ms. Nome: Jane Cognome: Turner Email: send email Telefono: 97226586668 Fax: 97225613205	IL (JERUSALEM)	participant	329˙920.00
7	METAPONTUM AGROBIOS S.R.L.  Organization address address: "STRADA STATALE IONICA 106 KM. 448,2 - FRAZIONE DI METAPONTO SNC" city: BERNALDA (MT) postcode: 75010 contact info Titolo: Dr. Nome: Angelo Cognome: Dichio Email: send email Telefono: 390836000000 Fax: 390836000000	IT (BERNALDA (MT))	participant	325˙440.00
8	PROPLANTA SRL  Organization address address: STR IOAN BUDAI DELEANU 28 city: Cluj Napoca postcode: 400474 contact info Titolo: Dr. Nome: Mihai Cognome: Socaciu Email: send email Telefono: 40741115673 Fax: 40264593792	RO (Cluj Napoca)	participant	209˙920.00
9	Agenzia Lucana di Sviluppo e di Innovazione in Agricoltura (ALSIA)  Organization address address: Via Carlo Levi 6/I city: Matera postcode: 75100 contact info Titolo: Dr. Nome: Rosanna Cognome: Caragiulo Email: send email Telefono: 390835000000 Fax: 390835000000	IT (Matera)	participant	0.00
10	THE JAMES HUTTON INSTITUTE  Organization address address: ERROL ROAD INVERGOWRIE city: DUNDEE postcode: DD2 5DA contact info Titolo: Ms. Nome: Karen Cognome: Robb Email: send email Telefono: 441383000000 Fax: 441383000000	UK (DUNDEE)	participant	0.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'In the METAPRO project we aim to optimise the production of several useful isoprenoid derived secondary metabolites to demonstrate the tools and strategies developed for the generic production of useful secondary metabolites in plants. Astaxanthin (ketocarotenoids) and the apocarotenoid crocin have been selected to demonstrate the application of the technologies adopted and developed. These compounds are of high-value and used in the industrial and health sectors. Both are classical secondary plant metabolites being formed in slow growing species that are not readily amenable to agricultural production. They are non-essential to the plant, synthesised at a defined developmental stage, in specialised tissues, cells and/or cellular compartments. In order to generate cheap renewable bio-resources of these compounds with improved economic and environmental potential, natural variation will be exploited and genetic engineering approaches implemented. Astaxanthin and crocin will be engineered into Solanaceae host platforms. Tomato fruit and potato tuber are ideal cell factories for this class of molecules, as at defined developmental stages their tissues and specialised cellular compartments are pre-disposed to high level isoprenoid formation. To optimise production in these hosts the METAPRO project aims to use modern and emerging technologies to (i) elucidate regulatory mechanisms involved in synthesis, (ii) optimise storage by increasing, altering and transport from, the cellular compartment responsible for synthesis and accumulation, (iii) improve stability of the products in the cell and during bioprocessing and (iv) implement improved transformation, transcription and translation tools for more efficient engineering and improved yields and quality. To achieve these objectives and deliver scientific excellence with impact a multidisciplinary pan-European team with complementary expertise, industrial (SME) participation and global interaction has been constructed.'

Introduzione (Teaser)

Isoprenoids (ISOs) are natural components of cosmetics and flavours, colourants and nutritional supplements in foods. Currently, ISOs are produced in low yields by slow-growing plant species that are not suitable for agricultural production.