MICROME

The Microme Project: A Knowledge-Based Bioinformatics Framework for Microbial Pathway Genomics

 Coordinatore EUROPEAN MOLECULAR BIOLOGY LABORATORY 

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Mr.
Nome: Tom
Cognome: Ratcliff
Email: send email
Telefono: +44 1223 494420
Fax: +44 1223 494468

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.microme.eu/
 Totale costo 7˙527˙543 €
 EC contributo 5˙263˙150 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2007-2A
 Funding Scheme CP-IP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-12-01   -   2013-11-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY

 Organization address address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117

contact info
Titolo: Mr.
Nome: Tom
Cognome: Ratcliff
Email: send email
Telefono: +44 1223 494420
Fax: +44 1223 494468

DE (HEIDELBERG) coordinator 876˙000.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Mr.
Nome: Régis
Cognome: Copin
Email: send email
Telefono: +33 1 60872506
Fax: +33 160872592

FR (PARIS 15) participant 567˙000.00
3    WAGENINGEN UNIVERSITY

 Organization address address: DROEVENDAALSESTEEG 4
city: WAGENINGEN
postcode: 6708 PB

contact info
Titolo: Mr.
Nome: Tom
Cognome: Bessems
Email: send email
Telefono: +31 317 484478

NL (WAGENINGEN) participant 464˙476.00
4    TEL AVIV UNIVERSITY

 Organization address address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
Titolo: Ms.
Nome: Lea
Cognome: Pais
Email: send email
Telefono: +972 3 640 8774
Fax: +972 3 640 9697

IL (TEL AVIV) participant 417˙152.00
5    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Mr.
Nome: Carlos Manuel
Cognome: Abad Ruiz
Email: send email
Telefono: +34 91 566 8852
Fax: +34 91 566 89 13

ES (MADRID) participant 375˙979.00
6    ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS

 Organization address address: CHARILAOU THERMI ROAD 6 KM
city: THERMI THESSALONIKI
postcode: 57001

contact info
Titolo: Prof.
Nome: Costas
Cognome: Kiparissides
Email: send email
Telefono: +30 2310 498210
Fax: +30 2310 498110

EL (THERMI THESSALONIKI) participant 375˙978.00
7    LEIBNIZ-INSTITUT DSMZ-DEUTSCHE SAMMLUNG VON MIKROORGANISMEN UND ZELLKULTUREN GMBH*

 Organization address address: Inhoffenstrasse 7B
city: BRAUNSCHWEIG
postcode: 38124

contact info
Titolo: Dr.
Nome: Heike
Cognome: Bauer
Email: send email
Telefono: +49 531 6181 2027
Fax: +49 531 6181 2299

DE (BRAUNSCHWEIG) participant 321˙999.00
8    GENOME RESEARCH LIMITED

 Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215
city: LONDON
postcode: NW1 2BE

contact info
Titolo: Mr.
Nome: David
Cognome: Davison
Email: send email
Telefono: +44 1223 494937
Fax: +44 1223 494919

UK (LONDON) participant 321˙756.00
9    SWISS INSTITUTE OF BIOINFORMATICS

 Organization address address: Rue Michel Servet 1
city: GENEVE
postcode: 1211

contact info
Titolo: Ms.
Nome: Jocelyne
Cognome: Bocquet
Email: send email
Telefono: +41 22 692 40 50
Fax: +41 21 692 40 55

CH (GENEVE) participant 275˙980.00
10    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

 Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029

contact info
Titolo: Dr.
Nome: Ralf
Cognome: Dahm
Email: send email
Telefono: +34 917 328 000
Fax: +34 912 246 980

ES (MADRID) participant 250˙481.00
11    UNIVERSITE LIBRE DE BRUXELLES

 Organization address address: Avenue Franklin Roosevelt 50
city: BRUXELLES
postcode: 1050

contact info
Titolo: Prof.
Nome: Jacques
Cognome: Van Helden
Email: send email
Telefono: +32 2 650 20 13
Fax: +32 2 650 54 25

BE (BRUXELLES) participant 250˙481.00
12    Isthmus

 Organization address address: Rue Saint Amand 31
city: Paris
postcode: 75015

contact info
Titolo: Dr.
Nome: Philippe
Cognome: Marlière
Email: send email
Telefono: +33 6 07 98 94 98
Fax: +33 1 60872514

FR (Paris) participant 242˙480.00
13    Molecular Networks GmbH - Computerchemie

 Organization address address: Henkestrasse 91
city: Erlangen
postcode: 91052

contact info
Titolo: Dr.
Nome: Christof H.
Cognome: Schwab
Email: send email
Telefono: +49 9131 815670
Fax: +49 9131 815669

DE (Erlangen) participant 239˙800.00
14    AMABIOTICS SAS

 Organization address address: RUE GASTON CREMIEUX 2
city: EVRY
postcode: 91000

contact info
Titolo: Ms.
Nome: Chantal
Cognome: Rougier
Email: send email
Telefono: +33 609761423
Fax: +33 142012058

FR (EVRY) participant 159˙496.77
15    Ceprodi Compagnie Europeenne de Produits Diabetiques

 Organization address address: Bd de Courcelles 67
city: Paris
postcode: 75008

contact info
Titolo: Mr.
Nome: David
Cognome: Dieumegard
Email: send email
Telefono: +33 1 56331526
Fax: +33 1 56331526

FR (Paris) participant 124˙091.24
16    HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH

 Organization address address: Inhoffenstrasse 7
city: BRAUNSCHWEIG
postcode: 38124

contact info
Titolo: Dr.
Nome: Michael
Cognome: Stratz
Email: send email
Telefono: +49 531 6181 2020
Fax: +49 531 6181 2299

DE (BRAUNSCHWEIG) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

environmental    resource    pathways    databases    genomes    models    biotechnology    pathway    annotation    assemblies    microbial    genome    functional    reactions    metabolic    pipeline    microme    clear    sequencing    species    generation   

 Obiettivo del progetto (Objective)

'The exponential increase in microbial genome and metagenome sequencing throughput has widened the gap between sequence and functional understanding. A clear picture of metabolic processes across the spectrum of bacterial species is essential to enable the exploitation of microbial genomics for the purposes of environmental biotechnology. The Microme project endeavors to extend the scope of microbial genome annotation from functional assignment at the gene level to the systematic generation of pathway assemblies and genome-scale metabolic models. A few key ideas and design principles will enable the Microme reconstruction pipeline to achieve this ambitious goal.A clear definition of a metabolic pathway as a collection of reaction sets, each of which convert the same defined inputs into the same outputs, will allow species-specific pathway variants to be identified, assembled into networks, compared across species, and used for downstream computations. A unique pathways projection, curation and assembly cycle, feeding directly into the flow of newly sequenced genomes, will allow a qualitative increase in the speed and reliability of the pathway generation process. Pathways and models produced the pipeline will be accessible to the scientific community as an integrated resource via the Microme portal. Finally, taking advantage of the availability of pathway assemblies from a large sample of genomes, methods for comparative and phylogenetic analyses and novel metabolic engineering strategies for environmental biotechnology goals will be developed, applied to proof-of-concept studies, and integrated to the resource as an analytical tool layer. Microme will be supported by a robust bioinformatics infrastructure, developed by integrating a set of established European databases and tools, integrated with reference protein annotation, metabolites and reactions databases, and interfaced with the annotation pipelines of the two main European sequencing centers.'

Introduzione (Teaser)

Sustainable economic development requires the use of new biological catalysts to perform synthesis and degradation reactions in an environmentally friendly way. The microbial world presents a reservoir of enzymatic reactions, with the vast majority of them waiting to be identified.

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