Coordinatore | EUROPEAN MOLECULAR BIOLOGY LABORATORY
Organization address
address: Meyerhofstrasse 1 contact info |
Nazionalità Coordinatore | Germany [DE] |
Sito del progetto | http://www.microme.eu/ |
Totale costo | 7˙527˙543 € |
EC contributo | 5˙263˙150 € |
Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
Code Call | FP7-KBBE-2007-2A |
Funding Scheme | CP-IP |
Anno di inizio | 2009 |
Periodo (anno-mese-giorno) | 2009-12-01 - 2013-11-30 |
# | ||||
---|---|---|---|---|
1 |
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Organization address
address: Meyerhofstrasse 1 contact info |
DE (HEIDELBERG) | coordinator | 876˙000.00 |
2 |
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Organization address
address: RUE LEBLANC 25 contact info |
FR (PARIS 15) | participant | 567˙000.00 |
3 |
WAGENINGEN UNIVERSITY
Organization address
address: DROEVENDAALSESTEEG 4 contact info |
NL (WAGENINGEN) | participant | 464˙476.00 |
4 |
TEL AVIV UNIVERSITY
Organization address
address: RAMAT AVIV contact info |
IL (TEL AVIV) | participant | 417˙152.00 |
5 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 375˙979.00 |
6 |
ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS
Organization address
address: CHARILAOU THERMI ROAD 6 KM contact info |
EL (THERMI THESSALONIKI) | participant | 375˙978.00 |
7 |
LEIBNIZ-INSTITUT DSMZ-DEUTSCHE SAMMLUNG VON MIKROORGANISMEN UND ZELLKULTUREN GMBH*
Organization address
address: Inhoffenstrasse 7B contact info |
DE (BRAUNSCHWEIG) | participant | 321˙999.00 |
8 |
GENOME RESEARCH LIMITED
Organization address
address: THE GIBBS BUILDING, EUSTON ROAD 215 contact info |
UK (LONDON) | participant | 321˙756.00 |
9 |
SWISS INSTITUTE OF BIOINFORMATICS
Organization address
address: Rue Michel Servet 1 contact info |
CH (GENEVE) | participant | 275˙980.00 |
10 |
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III
Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 contact info |
ES (MADRID) | participant | 250˙481.00 |
11 |
UNIVERSITE LIBRE DE BRUXELLES
Organization address
address: Avenue Franklin Roosevelt 50 contact info |
BE (BRUXELLES) | participant | 250˙481.00 |
12 |
Isthmus
Organization address
address: Rue Saint Amand 31 contact info |
FR (Paris) | participant | 242˙480.00 |
13 |
Molecular Networks GmbH - Computerchemie
Organization address
address: Henkestrasse 91 contact info |
DE (Erlangen) | participant | 239˙800.00 |
14 |
AMABIOTICS SAS
Organization address
address: RUE GASTON CREMIEUX 2 contact info |
FR (EVRY) | participant | 159˙496.77 |
15 |
Ceprodi Compagnie Europeenne de Produits Diabetiques
Organization address
address: Bd de Courcelles 67 contact info |
FR (Paris) | participant | 124˙091.24 |
16 |
HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
Organization address
address: Inhoffenstrasse 7 contact info |
DE (BRAUNSCHWEIG) | participant | 0.00 |
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
'The exponential increase in microbial genome and metagenome sequencing throughput has widened the gap between sequence and functional understanding. A clear picture of metabolic processes across the spectrum of bacterial species is essential to enable the exploitation of microbial genomics for the purposes of environmental biotechnology. The Microme project endeavors to extend the scope of microbial genome annotation from functional assignment at the gene level to the systematic generation of pathway assemblies and genome-scale metabolic models. A few key ideas and design principles will enable the Microme reconstruction pipeline to achieve this ambitious goal.A clear definition of a metabolic pathway as a collection of reaction sets, each of which convert the same defined inputs into the same outputs, will allow species-specific pathway variants to be identified, assembled into networks, compared across species, and used for downstream computations. A unique pathways projection, curation and assembly cycle, feeding directly into the flow of newly sequenced genomes, will allow a qualitative increase in the speed and reliability of the pathway generation process. Pathways and models produced the pipeline will be accessible to the scientific community as an integrated resource via the Microme portal. Finally, taking advantage of the availability of pathway assemblies from a large sample of genomes, methods for comparative and phylogenetic analyses and novel metabolic engineering strategies for environmental biotechnology goals will be developed, applied to proof-of-concept studies, and integrated to the resource as an analytical tool layer. Microme will be supported by a robust bioinformatics infrastructure, developed by integrating a set of established European databases and tools, integrated with reference protein annotation, metabolites and reactions databases, and interfaced with the annotation pipelines of the two main European sequencing centers.'
Sustainable economic development requires the use of new biological catalysts to perform synthesis and degradation reactions in an environmentally friendly way. The microbial world presents a reservoir of enzymatic reactions, with the vast majority of them waiting to be identified.