MINT

Multiphoton Ionization Nano-Therapy

Coordinatore	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Israel [IL]
Totale costo	1˙782˙600 €
EC contributo	1˙782˙600 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-StG
Funding Scheme	ERC-SG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-12-01   -   2014-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY  Organization address address: TECHNION CITY - SENATE BUILDING city: HAIFA postcode: 32000 contact info Titolo: Dr. Nome: Dvir Cognome: Yelin Email: send email Telefono: -8292864 Fax: -8293631	IL (HAIFA)	hostInstitution	1˙782˙600.00
2	TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY  Organization address address: TECHNION CITY - SENATE BUILDING city: HAIFA postcode: 32000 contact info Titolo: Mr. Nome: Mark Cognome: Davison Email: send email Telefono: -8292129 Fax: -8231990	IL (HAIFA)	hostInstitution	1˙782˙600.00

Mappa

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 Obiettivo del progetto (Objective)

'The application of nanotechnology for addressing key problems in clinical diagnosis and therapy holds great promise in medicine and in cancer in particular. Recent works have shown significant progress in nanoparticle-mediated drug delivery and therapy. In these applications, however, the small dimensions of the nanoparticles have been used primarily for efficient delivery and specificity, while the effects mediated by the nanoparticles occur away from the particle itself, affecting the entire celltumour volume. We propose to study and develop, for the first time, a novel scheme for cancer therapy that treats cancer cells at nanoscale resolutions. Briefly, when noble-metal nanoparticles are illuminated with femtosecond laser pulses tuned to their plasmonic resonance, order-of-magnitude enhancements of the optical fields several nanometres away from their surfaces lead to local damage only to nearby molecules or cellular organelles. This process, which practically involves no toxic agents, is at the basis for this proposal; we will utilize techniques for targeting nanoparticles to cells, initiate and control cancer cell destruction using nanoparticles and femtosecond laser pulses, and develop technology for conducting image-guided minimally invasive cancer therapy in remote locations of the body. Preliminary results supporting the proposed scheme include nonlinear optical imaging and ablation of living cells, in vivo endoscopic imaging of cancerous tumour nodules, and computer simulations of light-nanoparticle interactions. Using state-of-the-art concepts in nanotechnology, biology, chemistry, and medicine, the proposed novel multidisciplinary research will attempt at offering a feasible and safe addition to existing forms of cancer therapy.'