DYNA-MITO IN THYMUS

Role of mitochondria-shaping proteins in T cell development and migration in vivo

Coordinatore	UNIVERSITE DE GENEVE    more  Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Prof. Nome: Luca Cognome: Scorrano Email: send email Telefono: 41223795235 Fax: -
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	180˙801 €
EC contributo	180˙801 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-01   -   2011-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE DE GENEVE  Organization address address: Rue du General Dufour 24 city: GENEVE postcode: 1211 contact info Titolo: Prof. Nome: Luca Cognome: Scorrano Email: send email Telefono: 41223795235 Fax: -	CH (GENEVE)	coordinator	180˙801.44

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 Obiettivo del progetto (Objective)

'Mitochondria are highly dynamic organelles that continuously move, divide and fuse in a highly regulated fashion. The balance between the opposing processes of mitochondrial fusion and fission is controlled by a growing family of “mitochondria-shaping” proteins. Evidence is accumulating on the role of these proteins in several functions, from apoptosis to Ca2 signaling, to morphogenesis of dendritic spines and synapses, to regulation of migration of leukocytes. The knowledge of the regulation of mitochondrial dynamics, as well as its impact on tissue development and homeostasis is currently limited. This project hypothesizes that changes in mitochondrial morphology are crucial events in determining migration and development of T cells in the thymus. We will capitalize on the mouse models available in the host laboratory to (i) address whether mitochondrial dynamics regulates motility of lymphocytes in intact mouse thymic lobes; (ii) understand whether pro-fusion or pro-fission proteins regulate T cell development; (iii) dissect the role of fusion vs. antiapoptotic effect of pro-fusion protein in T cell migration and development. Our project is expected to clarify the role of mitochondrial dynamics in a complex immunological scenario like thymic development.'