SACP

Role of Senescence-associated Cysteine Proteases

Coordinatore	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.    more  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Prof. Nome: George Cognome: Coupland Email: send email Telefono: +49 221 5062 206 Fax: +49 221 5062 207
Nazionalità Coordinatore	Germany [DE]
Totale costo	160˙996 €
EC contributo	160˙996 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-03-01   -   2010-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Prof. Nome: George Cognome: Coupland Email: send email Telefono: +49 221 5062 206 Fax: +49 221 5062 207	DE (MUENCHEN)	coordinator	160˙996.90

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 Obiettivo del progetto (Objective)

'Despite the importance of senescence in world food production and safety, the proteases responsible for the massive protein degradation during senescence have not been identified. Strong candidates for senescence-associated proteases are members of various cysteine protease families that localize in lytic vacuoles that presumably engulf the chloroplast during senescence. This project aims at identifying the proteases that degrade chloroplasts in the model plant Arabidopsis thaliana. To detect and identify the active proteases during senescence the Activity-based Protease Profiling (ABPP) will be applied. ABPP is a novel functional proteomics technology based on the use of labeled small molecule inhibitors that label proteases in an activity-dependent manner. This technology can be used to show where, when and which proteases are active during senescence, and will reveal proteases that act redundantly. The role of these proteases in senescence will be further studied using reverse genetics and cell biological approaches. This project extends on the expertise and interest of the applicant in senescence and provides an excellent interdisciplinary training in cell biology, molecular cloning and state-of-the-art chemical biology. By performing this work in the Plant Chemetics lab at the Max Planck institute for Plant Breeding Research in Cologne, the applicant will have access to one of the best research and training facilities in Europe and leave at the end of the project with the knowledge and materials to establish an independent scientific career.'