BioEGOFET
Electrolyte-Gated Organic Field-Effect BIOsensors
| Coordinatore | UNIVERSITE PARIS DIDEROT - PARIS 7
Organization address
city: PARIS Cedex 13 contact info |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 2˙372˙347 € |
| EC contributo | 1˙830˙000 € |
| Programma | FP7-ICT
Specific Programme "Cooperation": Information and communication technologies |
| Code Call | FP7-ICT-2009-4 |
| Funding Scheme | CP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-02-01 - 2012-05-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITE PARIS DIDEROT - PARIS 7
Organization address
city: PARIS Cedex 13 contact info |
FR (PARIS Cedex 13) | coordinator | 0.00 |
| 2 |
ACREO AB.
Organization address
address: ELECTRUM 236 contact info |
SE (KISTA) | participant | 0.00 |
| 3 |
Ani Biotech Oy
Organization address
address: Museokatu contact info |
FI (Helsinki) | participant | 0.00 |
| 4 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Organization address
address: Rue Michel -Ange contact info |
FR (PARIS) | participant | 0.00 |
| 5 |
LINKOPINGS UNIVERSITET
Organization address
address: CAMPUS VALLA contact info |
SE (LINKOPING) | participant | 0.00 |
| 6 |
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Organization address
address: Vuorimiehentie contact info |
FI (ESPOO) | participant | 0.00 |
| 7 |
UNIVERSITA DEGLI STUDI DI BARI "ALDO MORO"
Organization address
address: Piazza Umberto I contact info |
IT (BARI) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
Electronic transduction can open new perspectives for point-of-care diagnosis and treatment monitoring. In this respect, label free, organic field-effect transistor (OFET) sensors have recently raised the interest of the organic-electronic community. The EGOFET biosensor aims at an electronic transduction of a bio-recognition event, eventually leading to an amplified response. The sensor combines the specificity of a defined bio-probe with the label-free and high sensitivity of the field-effect transduction principle. The recognition will be achieved through antigens, antibodies or membrane proteins placed on top of the organic semiconductor, right where the electrical transport occurs in this dielectrics/oxide-free structure. Supramolecular architectures will be used to immobilize the bio-probes into polymeric or phospholipid layers to maximise recognition capabilities and minimize non-specific binding and fouling. High sensitivity will be achieved by exploiting conformational changes and/or charge generation effects occurring upon the recognition process. To attain low-operating voltage and low-power consumption, the OFET will take advantage of the high capacitance offered by the electrolytic or protonic medium used to carry the analyte up to the semi-conductor surface. Implementation of the devices on paper and plastic substrates will be realized by low-cost printing-compatible technologies. The sensors figures of merit will be assessed by exploiting the highly specific biotin/avidin affinity reaction. A proof-of-principle for a point-of-care relevant application, using the immunoassay approach, will be pursued afterwards.