PATHOVIROME

Viral metagenomics of human pathologies with unknown etiology

 Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 

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 Nazionalità Coordinatore France [FR]
 Totale costo 831˙902 €
 EC contributo 831˙902 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-StG
 Funding Scheme ERC-SG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-02-01   -   2014-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Dr.
Nome: Christelle Marie
Cognome: Desnues
Email: send email
Telefono: +33 4 91324630
Fax: +33 4 9387772

FR (PARIS) hostInstitution 831˙902.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Béatrice
Cognome: Saint-Cricq
Email: send email
Telefono: +33 4 91164008
Fax: +33 4 91779304

FR (PARIS) hostInstitution 831˙902.00

Mappa


 Word cloud

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samples    pericarditis    pneumonia    etiology    viruses    diseases    pcr    unknown    encephalitis    viral   

 Obiettivo del progetto (Objective)

'While viral infections create an important threat for humanity, our knowledge of the viruses that infect humans is largely incomplete. So far, discovery of new viruses has been limited by the inability to propagate them in cell culture, the lack of serological cross-reactivity, or the absence of conserved genetic element to target by PCR. Thus, numerous acute and chronic diseases with unknown etiology are caused by yet unidentified viruses. Among the highest failure rates in determining the etiological cause of disease, pneumonia, encephalitis, and pericarditis are usually cited. In these cases, the search for unknown viruses is an urgent scientific task. We propose to identify new viruses, both indigenous and pathogenic, using metagenomics (shotgun Sanger sequencing and 454 pyrosequencing) of RNA and DNA from purified viral particles found in clinical samples of individuals presenting encephalitis, pneumonia, or pericarditis diseases without known etiology. Virus-centered bioinformatics methods will be developed to detect close as well as distant relatives of known viral species. Initial viral sequence similarity analysis will be followed by full viral genome reconstruction and phylogenetic analysis. The prevalence, abundance, and geographical distribution of newly identified viruses will then be determined using quantitative real-time PCR and RT-PCR on a 10-year collection of samples from extensively characterized patients.'

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