NANOPUZZLE

Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design

Coordinatore	UNIVERSIDAD DE ZARAGOZA    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Spain [ES]
Totale costo	1˙541˙310 €
EC contributo	1˙541˙310 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-StG
Funding Scheme	ERC-SG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-02-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSIDAD DE ZARAGOZA  Organization address address: CALLE PEDRO CERBUNA 12 city: Zaragoza postcode: 50009 contact info Titolo: Dr. Nome: Jesús Cognome: Martínez De La Fuente Email: send email Telefono: +34 876 552982 Fax: +34 976 762776	ES (Zaragoza)	hostInstitution	1˙541˙310.00
2	UNIVERSIDAD DE ZARAGOZA  Organization address address: CALLE PEDRO CERBUNA 12 city: Zaragoza postcode: 50009 contact info Titolo: Ms. Nome: Carmen Cognome: Baras Email: send email Telefono: +34 976 76 10 00 Fax: +34 976 76 10 48	ES (Zaragoza)	hostInstitution	1˙541˙310.00

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 Obiettivo del progetto (Objective)

'Nature has been utilizing nanostructures for billion of years. The following two properties, (i) being about the size of typical biological objects and (ii) the possibility of tailoring their properties by changing their size, make nanoparticles attractive for biomedical applications. Using nanoparticles to deliver drugs to tumours offers an attractive possibility to avoid obstacles that occur during conventional systemic drug administration. This NANOPUZZLE project pretends to develop an innovative controlled release methodology, based on hyperthermia and magnetic nanoparticles, as platform for the incorporation of different molecules with different functionalities, to obtain a multifunctional system for cancer treatment and diagnose that leads antitumoral drugs discharge only in the tumoral area. Multifunctional magnetic nanoparticles loaded with a targeting agent (folic acid) and a potent antitumoral drug (doxorubicin) will be prepared. These active molecules will be coupled to the magnetic nanoparticles (MNPs) due to complementary oligonucleotides strands (oligo-zipper). Due to the magnetic properties of these nanomaterials, a local heating induced by an alternating magnetic field, will release the drug in the desired target as a consequence of the DNA denaturation (oligo-unzipping). For this approach, the increase of temperature is only required directly in the nanoparticles and the heating of the surroundings is not needed. For instance, less quantity of nanoparticles and a weaker external magnetic field will be required, avoiding the main inconveniences of conventional hyperthermia treatments. Furthermore, the superparamagnetic properties of these MNPs will also allow their use as contrast agents for tracking and diagnosis by magnetic resonance imaging (MRI).'