ADORA

Structural and Functional Studies of Human Adenosine A2A Receptor G protein Complex: Toward Understanding GPCR Activation

Coordinatore	OULUN YLIOPISTO    more  Organization address address: Pentti Kaiteran Katu 1 city: OULU postcode: 90014 contact info Titolo: Dr. Nome: Leila Cognome: Risteli Email: send email Telefono: -5533653 Fax: -4176
Nazionalità Coordinatore	Finland [FI]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-RG
Funding Scheme	MC-IRG
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-10-01   -   2013-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	OULUN YLIOPISTO  Organization address address: Pentti Kaiteran Katu 1 city: OULU postcode: 90014 contact info Titolo: Dr. Nome: Leila Cognome: Risteli Email: send email Telefono: -5533653 Fax: -4176	FI (OULU)	coordinator	100˙000.00

Mappa

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 Obiettivo del progetto (Objective)

'This application is to partially fund a junior research position at the Oulu Biocenter (BCO) and the Department of Biochemistry, University of Oulu, concerning structural determination of human adenosine receptor subtype selectivity and allosteric modulation. As a basis of this project, we recently determined the crystal structure of the human adenosine A2A receptor. By the research described in the research plan, we will accomplish one or more of following goals (2010-2014): To solve human adenosine A1, A2A, A2B and A3 structure complexes with subtype-selective ligands and co-factors. To study allosteric modulation of adenosine receptors. To study the functional/structural role of lipids those were co-crystallized in the initial A2A structure. To determine the structure of carboxy terminal domain(s) of human A2A receptor and further characterize its functional properties and interaction partners. To biophysically characterize the dynamic and conformational changes upon ligand/co-factor binding in the purified adenosine receptor those are important to the activation mechanism. The main goal is to establish an independent research team and equipments at the BCO. The team would be specialized on structural and functional studies of GPCRs. The BCO and the protein science facilities available at Oulu University provides excellent environment for the research proposed, with access to instruments and facilities needed for the proposed research. The major collaborators in this project include R.C.Stevens (the Scripps Research Institute, USA) and A. Ijzeman (University of Leiden, Netherlands). We will seek more collaboration nationally and internationally on GPCRs and biophysical characterization of the targets. With this application, partial salary of the PI is applied. The BCO is committed support a start up package for setting up a laboratory, an annual grant for materials and consumables and salary for two other project members for this proposal.'

Introduzione (Teaser)

Adenosine is important for the normal function of nerve cells, controlling cell proliferation, and as a signal of inflammation. Adenosine cell surface receptors called A2A play a critical role in facilitating such functions.