ARIADNE
Signaling circuitry controlling fungal virulence: identification and characterization of conserved and specific fungal virulence genes as common antifungal targets
| Coordinatore | CARLSBERG AS
Organization address
address: NY CARLSBERG VEJ 100 contact info |
| Nazionalità Coordinatore | Denmark [DK] |
| Totale costo | 2˙908˙908 € |
| EC contributo | 2˙908˙908 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-ITN-2008 |
| Funding Scheme | MC-ITN |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-01-01 - 2014-05-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CARLSBERG AS
Organization address
address: NY CARLSBERG VEJ 100 contact info |
DK (KOBENHAVN) | coordinator | 678˙224.00 |
| 2 |
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
Organization address
address: KING'S COLLEGE REGENT WALK contact info |
UK (ABERDEEN) | participant | 413˙704.00 |
| 3 |
MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Organization address
address: Hofgartenstrasse 8 contact info |
DE (MUENCHEN) | participant | 392˙208.00 |
| 4 |
UNIVERSIDAD DE CORDOBA
Organization address
address: AVENIDA DE MEDINA AZAHARA 5 contact info |
ES (CORDOBA) | participant | 391˙620.00 |
| 5 |
THE UNIVERSITY OF EXETER
Organization address
address: Northcote House, The Queen's Drive contact info |
UK (EXETER) | participant | 226˙388.00 |
| 6 |
LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS KNOELL INSTITUTE
Organization address
address: Beutenbergstrasse 11a contact info |
DE (JENA) | participant | 214˙531.00 |
| 7 |
BAYER CROPSCIENCE SA
Organization address
address: RUE JEAN MARIE LECLAIR 16 contact info |
FR (LYON) | participant | 201˙552.00 |
| 8 |
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Organization address
address: Rue De L'Universite 147 contact info |
FR (PARIS CEDEX 07) | participant | 201˙552.00 |
| 9 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 189˙129.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'Fungi are heterotrophic microorganisms with devastating impact on agriculture and human health. Agricultural production worth billions of € is destroyed annually by fungal diseases. Human fungal infections have severe consequences on the growing number of immuno-compromised patients, with high mortality rates associated with Aspergillus and Candida infections. There is a critical need to further the development of new antifungals, which requires a comprehensive molecular knowledge on fungal pathogenesis and signal transduction. ARIADNE uses a comparative biological approach at the systems biology level to identify and validate signalling target genes that play an essential causative role in fungal virulence on both plant and human hosts. To establish a comprehensive view of fungal pathogenesis seven pathogenic species will be studied, including the two major fungal pathogens of humans Aspergillus fumigatus and Candida albicans, the devastating plant pathogens Fusarium oxysporum, Magnaporthe grisea and Mycospherella graminicola, as well as two established model pathogens of filamentous and dimorphic fungi, Ashbya gossypii and Ustilago maydis. This array of fungal species cuts across diverse taxonomic groups, covering several hundred million years of evolution. The central scientific and technological challenges for ARIADNE are to 1) integrate parallel transcriptomics, proteomics, and chemical genetics for a comprehensive set of major fungal pathogens, 2) identify evolutionarily conserved and species specific signalling effectors which act as key players in fungal virulence, 3) validate these proteins as candidate targets for small molecule inhibitors. This groundbreaking scientific and teaching approach will open up new avenues on how to look at fungal pathogenicity and will generate an unprecedented knowledge platform, which will facilitate the discovery and validation of antifungal targets in both the agricultural and the pharmaceutical sectors.'
Introduzione (Teaser)
European researchers have formulated a new integrated approach to the devastating effects of fungal diseases. Molecular knowledge of virulence mechanisms combined with training of scientists in a cross-sectorial environment has yielded significant results in the fight against fungal infection.