ULTRANMR
Ultrafast Hyperpolarized NMR and MRI in Multiple Dimensions
| Coordinatore | WEIZMANN INSTITUTE OF SCIENCE
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | Israel [IL] |
| Totale costo | 2˙499˙780 € |
| EC contributo | 2˙499˙780 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2009-AdG |
| Funding Scheme | ERC-AG |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-03-01 - 2015-02-28 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
WEIZMANN INSTITUTE OF SCIENCE
Organization address
address: HERZL STREET 234 contact info |
IL (REHOVOT) | hostInstitution | 2˙499˙780.00 |
| 2 |
WEIZMANN INSTITUTE OF SCIENCE
Organization address
address: HERZL STREET 234 contact info |
IL (REHOVOT) | hostInstitution | 2˙499˙780.00 |
Mappa
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Obiettivo del progetto (Objective)
'Multidimensional nuclear magnetic resonance (nD NMR) plays a unique role in Science as a primary tool for the characterization of biomolecules, as part of drug-discovery processes, and in clinical imaging (MRI). Further progress in NMR is hampered by this spectroscopy s low sensitivity, arising from the weak interactions that it involves. The prospects of solving this problem by continuing with incremental bigger machines approaches are poor, given the high maturity reached by existing technologies. The present Project deals with this issue by departing from traditional concepts, and relying on two incipient but highly promising developments in the field. One of these pertains ex situ dynamic nuclear hyperpolarization, an approach capable of eliciting liquid state NMR signals that surpass those afforded by the highest-field spectrometers by factors e10,000. While capable of providing super-signals hyperpolarization has the drawback of involving irreversible changes in the physical state of the sample. This makes it incompatible with nD NMR technologies, requiring the collection of multiple scans identical to one another except for systematic delay variations. As second component in this high-risk/high-gain Project we propose merging hyperpolarization with "ultrafast" methods that we have recently developed for completing arbitrary nD NMR/MRI acquisitions within a single scan. The resulting synergy could increase sensitivity by orders of magnitude, while demanding negligibly small amounts of spectrometer/scanner time to complete nD acquisitions. This should provide an ideal starting point for the analysis of a variety of organic and structural biology problems, and provide new tools to explore in vivo metabolism focusing on cancer biomarkers.'