PIROVAC
Improvement of current and development of new vaccines for theileriosis and babesios of small ruminants
| Coordinatore | FORSCHUNGSZENTRUM BORSTEL
Organization address
address: Parkallee 1-40 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 4˙059˙031 € |
| EC contributo | 2˙999˙994 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2009-3 |
| Funding Scheme | CP-FP-SICA |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-04-01 - 2014-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
FORSCHUNGSZENTRUM BORSTEL
Organization address
address: Parkallee 1-40 contact info |
DE (BORSTEL) | coordinator | 835˙890.00 |
| 2 |
UNIVERSITY OF GLASGOW
Organization address
address: University Avenue contact info |
UK (GLASGOW) | participant | 254˙500.00 |
| 3 |
THE ROYAL VETERINARY COLLEGE
Organization address
address: Royal College Street contact info |
UK (LONDON) | participant | 200˙000.00 |
| 4 |
THE UNIVERSITY OF EDINBURGH
Organization address
address: OLD COLLEGE, SOUTH BRIDGE contact info |
UK (EDINBURGH) | participant | 200˙000.00 |
| 5 |
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Organization address
address: BERNHARD NOCHT STRASSE 74 contact info |
DE (HAMBURG) | participant | 180˙000.00 |
| 6 |
LANZHOU VETERINARY RESEARCH INSTITUTE
Organization address
address: Xujiaping 11 contact info |
CN ("Lanzhou, Gansu") | participant | 180˙000.00 |
| 7 |
Intervet International B.V.
Organization address
address: WIM DE KORVERSTRAAT 35 contact info |
NL (BOXMEER) | participant | 179˙104.00 |
| 8 |
PARCO TECNOLOGICO PADANO S.R.L.
Organization address
address: Via Einstein - Localita Cascina Codazza contact info |
IT (LODI) | participant | 170˙000.00 |
| 9 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | participant | 150˙000.00 |
| 10 |
UNIVERSITAET BERN
Organization address
address: Hochschulstrasse 4 contact info |
CH (BERN) | participant | 150˙000.00 |
| 11 |
ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE
Organization address
address: Site de la Chantrerie, Route de Gachet contact info |
FR (NANTES) | participant | 130˙000.00 |
| 12 |
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Organization address
address: Av. da Republica, Quinta do Marques S/N contact info |
PT (OEIRAS) | participant | 130˙000.00 |
| 13 |
INSTITUTO NACIONAL DE TECNOLOGIA AGROPECUARIA
Organization address
address: Rivadavia 1439 contact info |
AR (BUENOS AIRES) | participant | 100˙000.00 |
| 14 |
MINISTRY OF AGRICULTURE AND RURAL DEVELOPMENT
Organization address
address: . contact info |
IL (BEIT DAGAN) | participant | 80˙500.00 |
| 15 |
ADNAN MENDERES UNIVERSITESI
Organization address
address: "Adnan Menderes Universitesi Rektorlugu, Merkez Kampus Aytepe Mvkii" contact info |
TR (AYDIN) | participant | 60˙000.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'The proposal deals with the establishment of control measures for two major tick-borne diseases of small ruminants: theileriosis caused by Theileria lestoquardi and T. uilenbergi and babesiosis caused by Babesia ovis. The research programme aims at improving existing and producing new attenuated vaccines, designing subunit vaccines and capability building. To achieve these goals the proposal will assess parasite diversity and identify molecules associated with attenuation of parasite virulence to be included in the development of safe and efficacious live vaccines. For the design of a subunit vaccine parasite molecules will be identified and characterized involved in i) invasion of host cells ii) activation of CD4 T cells and NK cells for the production of cytokines capable of activating macrophages for killing of the parasites and iii) activation of cytotoxic T-lymphocytes involved in killing of T. lestoquardi-infected leucocytes. For improvement of attenuated vaccines, a combination of vaccine with subunit vaccine will be examined for synergistic effects and reducing the need of a cold chain by improving storage conditions/ shelf life of vaccine will be aimed for. Groups working on Plasmodium are involved with the goal to benefit from the scientific and technological knowledge in this field and to translate it into tools and reagents for small ruminant piroplasms. Industrial expertise regarding vaccine development and delivery systems will be incorporated in the whole project. The impact of the vaccine to be produced against these emerging tick-borne diseases will be enormous, as they pose a great threat to livestock production, and a contribution will be made that will meet critical Millennium development goals: food security, food safety, poverty alleviation, animal welfare and environmental sustainability.'
Introduzione (Teaser)
Tick-borne parasitic infections are common in small ruminants such as sheep, goats, deer and other related species. Through a combination of immunology, genomics and vaccinology, researchers from 11 countries investigated ways to improve existing vaccines and create new ones.
Altri progetti dello stesso programma (FP7-KBBE)
ARBO-ZOONET (2008)
International network for capacity building for the control of emerging viral vector borne zoonotic diseases
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