PHOSCHEMREC

"Recognition and Cleavage of Biological Phosphates – Molecular Recognition, Mechanism and Biomedical Applications"

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333 543 Fax: +44 1223 332 988
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙535˙051 €
EC contributo	2˙535˙051 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-ITN-2008
Funding Scheme	MC-ITN
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-07-01   -   2014-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Ms. Nome: Renata Cognome: Schaeffer Email: send email Telefono: +44 1223 333 543 Fax: +44 1223 332 988	UK (CAMBRIDGE)	coordinator	320˙844.00
2	TURUN YLIOPISTO  Organization address address: YLIOPISTONMAKI city: TURUN YLIOPISTO postcode: 20014 contact info Titolo: Dr. Nome: Eliisa Cognome: Sarkilahti Email: send email Telefono: +358 2 333 6155 Fax: +358 2 333 6446	FI (TURUN YLIOPISTO)	participant	511˙120.00
3	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Cecilia Cognome: Tilly Email: send email Telefono: +46 8 608 91 03 Fax: +46 8 608 92 80	SE (STOCKHOLM)	participant	416˙413.00
4	THE UNIVERSITY OF SHEFFIELD  Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN contact info Titolo: Ms. Nome: Joanne Cognome: Watson Email: send email Telefono: +44 114 222 4754 Fax: +44 114 222 1455	UK (SHEFFIELD)	participant	275˙957.00
5	UNIVERSITA DEGLI STUDI DI PADOVA  Organization address address: VIA 8 FEBBRAIO 2 city: PADOVA postcode: 35122 contact info Titolo: Prof. Nome: Armando Cognome: Gennaro Email: send email Telefono: 390498000000 Fax: 390498000000	IT (PADOVA)	participant	211˙339.00
6	AVARIS AB  Organization address address: "C/O Karolisnka Innovations AB, Fogdevreten 2B" city: STOCKHOLM postcode: 17177 contact info Titolo: Dr. Nome: Anna Cognome: Bergan Email: send email Telefono: +46 8 779 40 60 Fax: +46 8 779 40 61	SE (STOCKHOLM)	participant	204˙298.00
7	JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN  Organization address address: GRUNEBURGPLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 contact info Titolo: Ms. Nome: Mareike Cognome: Schmitt Email: send email Telefono: +49 69 798 25194 Fax: +49 69 798 25007	DE (FRANKFURT AM MAIN)	participant	201˙879.00
8	UNIVERSITEIT GENT  Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 contact info Titolo: Ms. Nome: Nathalie Cognome: Vandepitte Email: send email Telefono: +32 9 264 3029 Fax: +32 9 264 3583	BE (GENT)	participant	199˙785.00
9	OLIGOMER SCIENCES AB  Organization address address: SVEAVAGEN 18A city: DJURSHOLM postcode: 182 60 contact info Titolo: Dr. Nome: Malgorzata Cognome: Honcharenko Email: send email Telefono: 46762686729	SE (DJURSHOLM)	participant	193˙416.00
10	Wallac Oy  Organization address address: Mustionkatu 6 city: Turku postcode: 20750 contact info Titolo: Dr. Nome: Jari Cognome: Hovinen Email: send email Telefono: +358 2 267 8111 Fax: +358 2 267 8305	FI (Turku)	participant	0.00

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 Obiettivo del progetto (Objective)

'Chemical Biology is a new, supradisciplinary field that unites the classically separate disciplines of Chemistry and Biology. This network is centred around understanding the central biological process of phosphate transfer and combines leading experts in synthetic chemistry, enzyme model building, kinetic analysis, protein chemistry and directed evolution in a concerted effort to gain a quantitative understanding of transition states that are key to understanding how biological systems can achieve phosphate transfer with unrivalled efficiency. The quantitative language (i.e. kinetic and molecular recognition studies) used to describe and improve natural enzymes unites all participants and provides the theme for our training programme on analysis of phosphate transfer catalysis. Training in this area is highly interdisciplinary in nature requiring a joint effort of chemists and biologists centred around mechanistic thinking, which is at the core of this proposal. Ultimately our understanding of this central bioreaction should lead to useful applications on the long term, e.g. as artificial nucleases, with potential roles in gene regulation, if efficient catalysis can be combined with selective recognition. This proposal is part of a long-term strategy aimed at developing reagents which act by binding or catalytically (thus as artificial enzymes) to interfere with the expression of specific genes. This can be achieved through selective binding eventually (but not necessarily) followed by cleaving the nucleic acid backbone. Crucially for therapeutic success these reagents have to be deliverd into the cell, which is why delivery issues are also addressed. The incorporation of industrial partners ensures that the full life-span of drug development is covered in this training programme.'