PHOSCHEMREC
"Recognition and Cleavage of Biological Phosphates – Molecular Recognition, Mechanism and Biomedical Applications"
| Coordinatore | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 2˙535˙051 € |
| EC contributo | 2˙535˙051 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-ITN-2008 |
| Funding Scheme | MC-ITN |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-07-01 - 2014-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | coordinator | 320˙844.00 |
| 2 |
TURUN YLIOPISTO
Organization address
address: YLIOPISTONMAKI contact info |
FI (TURUN YLIOPISTO) | participant | 511˙120.00 |
| 3 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 416˙413.00 |
| 4 |
THE UNIVERSITY OF SHEFFIELD
Organization address
address: FIRTH COURT WESTERN BANK contact info |
UK (SHEFFIELD) | participant | 275˙957.00 |
| 5 |
UNIVERSITA DEGLI STUDI DI PADOVA
Organization address
address: VIA 8 FEBBRAIO 2 contact info |
IT (PADOVA) | participant | 211˙339.00 |
| 6 |
AVARIS AB
Organization address
address: "C/O Karolisnka Innovations AB, Fogdevreten 2B" contact info |
SE (STOCKHOLM) | participant | 204˙298.00 |
| 7 |
JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN
Organization address
address: GRUNEBURGPLATZ 1 contact info |
DE (FRANKFURT AM MAIN) | participant | 201˙879.00 |
| 8 |
UNIVERSITEIT GENT
Organization address
address: SINT PIETERSNIEUWSTRAAT 25 contact info |
BE (GENT) | participant | 199˙785.00 |
| 9 |
OLIGOMER SCIENCES AB
Organization address
address: SVEAVAGEN 18A contact info |
SE (DJURSHOLM) | participant | 193˙416.00 |
| 10 |
Wallac Oy
Organization address
address: Mustionkatu 6 contact info |
FI (Turku) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Chemical Biology is a new, supradisciplinary field that unites the classically separate disciplines of Chemistry and Biology. This network is centred around understanding the central biological process of phosphate transfer and combines leading experts in synthetic chemistry, enzyme model building, kinetic analysis, protein chemistry and directed evolution in a concerted effort to gain a quantitative understanding of transition states that are key to understanding how biological systems can achieve phosphate transfer with unrivalled efficiency. The quantitative language (i.e. kinetic and molecular recognition studies) used to describe and improve natural enzymes unites all participants and provides the theme for our training programme on analysis of phosphate transfer catalysis. Training in this area is highly interdisciplinary in nature requiring a joint effort of chemists and biologists centred around mechanistic thinking, which is at the core of this proposal. Ultimately our understanding of this central bioreaction should lead to useful applications on the long term, e.g. as artificial nucleases, with potential roles in gene regulation, if efficient catalysis can be combined with selective recognition. This proposal is part of a long-term strategy aimed at developing reagents which act by binding or catalytically (thus as artificial enzymes) to interfere with the expression of specific genes. This can be achieved through selective binding eventually (but not necessarily) followed by cleaving the nucleic acid backbone. Crucially for therapeutic success these reagents have to be deliverd into the cell, which is why delivery issues are also addressed. The incorporation of industrial partners ensures that the full life-span of drug development is covered in this training programme.'