GPC IN BMP SIGNALING

Glypican5-supported endocytic control of BMP4 signaling

Coordinatore	VIB    more  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Rik Cognome: Audenaert Email: send email Telefono: -2446588 Fax: -2446587
Nazionalità Coordinatore	Belgium [BE]
Totale costo	159˙100 €
EC contributo	159˙100 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-07-01   -   2012-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	VIB  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Rik Cognome: Audenaert Email: send email Telefono: -2446588 Fax: -2446587	BE (ZWIJNAARDE - GENT)	coordinator	159˙100.00

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 Obiettivo del progetto (Objective)

'Increasingly, the glypicans, major membrane proteins that supply heparan sulfate at the surface of cells, emerge as essential for the reception and dissemination of morphogenetic signals. While the best recognized role of endocytosis in signaling is to down-regulate the signal by sending the receptor and/or the ligand to degradative compartments such as lysosomes, it has now become clear that endocytosis also contributes to activation of signalling. In this project, we propose to explore the importance of glypicans for mechanisms of endocytic/exocytic trafficking and fine-tuning of signalling. We suspect that, by associating with specific protein sorting and trafficking machineries, glypicans control the formation of distinctive ‘signalling endosomes’, involved in the transcytosis of HS-cargo and its recycling to the cell surface, influencing what signal-transduction machineries are activated, where they are activated, and for how long. This working hypothesis is explored, concentrating on the effect of Glypican-5 on Bmp-4 signaling, in vitro, by cellular and biochemical assays, tracing glypican and glypican-interacting proteins, and by functional interference, using siRNA, and in vivo, in zebra fish embryos, using the injection of anti-sense morpholinos and mRNAs. Using these combined and integrated approaches in test tubes, cells and model organisms, we expect identifying novel mechanisms of vesicular trafficking that are important for development, developmental disorders, and acquired disease. In general, this project proposed will support the career development of the researcher by enhancing her competence diversification through a complete training. This fellowship is an opportunity for the applicant to attain a leading independent position.'