TNSBSLD

Targeting nucleic acid structures by site-directed ligand discovery

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Mr. Nome: Keith Cognome: Cann Email: send email Telefono: -334722 Fax: -334167
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	172˙240 €
EC contributo	172˙240 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-05-01   -   2012-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Mr. Nome: Keith Cognome: Cann Email: send email Telefono: -334722 Fax: -334167	UK (CAMBRIDGE)	coordinator	172˙240.80

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 Obiettivo del progetto (Objective)

Nucleic acids and nucleic acid-protein interactions play an important role in biological processes of medical importance and can be considered as attractive targets for drug design. Small molecules or peptides that interact with such targets and control their functions are of great interest. Thus there is a need for a general method for rapidly identifying such low molecular weight small molecules or peptides. The focus of this proposal is to establish a new method based on a combined fragment-based and site-directed approach that exploits the power of dynamic combinatorial chemistry (DCC). This method will be used as a general strategy to target functional nucleic acid structures and their protein complexes.