WOUNDHEALINGEGF

The role of EGF/ERK signaling pathway during the wound healing response in Drosophila and zebrafish epithelia

Coordinatore	INSTITUTO DE MEDICINA MOLECULAR    more  Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 contact info Titolo: Dr. Nome: Margarida Cognome: Pinto Gago Email: send email Telefono: 351218000000 Fax: 351218000000
Nazionalità Coordinatore	Portugal [PT]
Totale costo	146˙783 €
EC contributo	146˙783 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-09-01   -   2012-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUTO DE MEDICINA MOLECULAR  Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 contact info Titolo: Dr. Nome: Margarida Cognome: Pinto Gago Email: send email Telefono: 351218000000 Fax: 351218000000	PT (LISBOA)	coordinator	146˙783.60

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Epithelia act as physical barriers that protect living organisms from the surrounding environment. Therefore, the organization and homeostasis in epithelial tissues requires robust mechanisms that assure their integrity in a variety of biological situations, such as normal cell turnover, inflammation and injury. The cell biology of wound healing has started to be understood but there are still many open questions and the signaling cascades that regulate this process are largely unknown. An intriguing and crucial question is what is the nature of the earliest signals that activate the different events of a wound response. In this project, we will study the signaling pathways required for the activation of the wound response. Our main focus will be the role of EGF/ERK signaling, which we propose to be one of the first pathways to be activated in this process. We also plan to determine the primary signals activating the wound response cascades. We will use the Drosophila embryonic and pupal epithelia as our primary model systems, but will also investigate whether these signaling mechanisms are conserved in vertebrates, by studying the wound healing process in zebrafish embryonic epithelia.'