EFFECTOR FUNCTION

Discovering the role of AVRblb2 in suppression of chitin triggered plant immunity

Coordinatore	THE SAINSBURY LABORATORY    more  Organization address address: "Norwich Research Park, Colney Lane" city: NORWICH postcode: NR47UH contact info Titolo: Ms. Nome: Debbie Cognome: Feather Email: send email Telefono: +44 1603 450420 Fax: +44 1603 450011
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	30˙000 €
EC contributo	30˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-RG
Funding Scheme	MC-ERG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-09-01   -   2012-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE SAINSBURY LABORATORY  Organization address address: "Norwich Research Park, Colney Lane" city: NORWICH postcode: NR47UH contact info Titolo: Ms. Nome: Debbie Cognome: Feather Email: send email Telefono: +44 1603 450420 Fax: +44 1603 450011	UK (NORWICH)	coordinator	30˙000.00

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 Obiettivo del progetto (Objective)

'Phytophthora infestans causes the re-emerging and devastating late blight disease, which threatens potato and tomato production worldwide. With the recent publication of the P. infestans genome, it has become clear that this hemibiotrophic pathogen secretes hundreds of effector proteins to modulate plant immunity and enable colonization. Therefore, my long-term aim is to reveal the mode of action of P. infestans effectors and to analyze host molecular mechanisms that are perturbed by this devastating pathogen. Thereby, I plan to generate valuable information for the scientific community that will help to develop novel strategies to fight against plant pathogens and contribute to addressing the issue of food security. Plant innate immunity relies on pattern recognition receptors that recognize pathogen associated molecular patterns (PAMPs) such as chitin. Given that oomycetes contain some chitin in their cell wall, we decided to investigate the role of chitin recognition in plant immunity against oomycetes. The overall objective of this proposal is to elucidate the mechanism of suppression of chitin elicitor signalling by P. infestans RXLR effector AVRblb2, and to identify host components involved in this process. The rationale behind this research is based on our exciting preliminary data, which showed that (i) silencing of Cerk1 in Nicotiana benthamiana increased susceptibility towards P. infestans infection, (ii) AVRblb2 suppressed the defense responses induced by chitin, and (iii) heterologous expression of AVRblb2 in N. benthamiana increased susceptibility towards P. infestans infection. We aim to determine the extent of suppression of PAMP triggered immunity (PTI) by AVRblb2 and identify the potential mechanism of suppression. We will use a multifaceted approach including genetic, biochemical, and cell imaging methods to functionally characterize suppression of PTI by AVRblb2 and elucidate the role of chitin recognition in plant immunity against P. infestans.'